Low susceptibility of asunaprevir towards R155K and D168A point mutations in HCV NS3/4A protease: A molecular dynamics simulation

Low susceptibility of asunaprevir towards R155K and D168A point mutations in HCV NS3/4A protease: A molecular dynamics simulation

© 2019 Elsevier Inc. Hepatitis C has become an important health problem that requires expensive treatment and leads to liver tumorigenesis. Hepatitis C virus (HCV), which is the main cause of hepatitis C, has a high mutation rate due to the lack of proofreading activity of the RNA polymerase enzyme....

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Bibliographic Details
Main Authors: Jirayu Kammarabutr, Panupong Mahalapbutr, Bodee Nutho, Nawee Kungwan, Thanyada Rungrotmongkol
Format: Journal
Published: 2019
Subjects:
Chemistry
Computer Science
Materials Science
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062853645&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/65482
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Institution: Chiang Mai University

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http://cmuir.cmu.ac.th/jspui/handle/6653943832/65482

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