Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV

© 2019 Alterations in subcortical brain structures have been reported in adults with HIV and, to a lesser extent, pediatric cohorts. The extent of longitudinal structural abnormalities in children with perinatal HIV infection (PaHIV) remains unclear. We modeled subcortical morphometry from whole bra...

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Main Authors: Benjamin S.C. Wade, Victor G. Valcour, Thanyawee Puthanakit, Arvin Saremi, Boris A. Gutman, Talia M. Nir, Christa Watson, Linda Aurpibul, Pope Kosalaraksa, Pradthana Ounchanum, Stephen Kerr, Netsiri Dumrongpisutikul, Pannee Visrutaratna, Jiraporn Srinakarin, Monthana Pothisri, Katherine L. Narr, Paul M. Thompson, Jintanat Ananworanich, Robert H. Paul, Neda Jahanshad
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Published: 2019
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/65843
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spelling th-cmuir.6653943832-658432019-08-05T04:42:19Z Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV Benjamin S.C. Wade Victor G. Valcour Thanyawee Puthanakit Arvin Saremi Boris A. Gutman Talia M. Nir Christa Watson Linda Aurpibul Pope Kosalaraksa Pradthana Ounchanum Stephen Kerr Netsiri Dumrongpisutikul Pannee Visrutaratna Jiraporn Srinakarin Monthana Pothisri Katherine L. Narr Paul M. Thompson Jintanat Ananworanich Robert H. Paul Neda Jahanshad Medicine Neuroscience © 2019 Alterations in subcortical brain structures have been reported in adults with HIV and, to a lesser extent, pediatric cohorts. The extent of longitudinal structural abnormalities in children with perinatal HIV infection (PaHIV) remains unclear. We modeled subcortical morphometry from whole brain structural magnetic resonance imaging (1.5 T) scans of 43 Thai children with PaHIV (baseline age = 11.09±2.36 years) and 50 HIV− children (11.26±2.80 years) using volumetric and surface-based shape analyses. The PaHIV sample were randomized to initiate combination antiretroviral treatment (cART) when CD4 counts were 15–24% (immediate: n = 22) or when CD4 < 15% (deferred: n = 21). Follow-up scans were acquired approximately 52 weeks after baseline. Volumetric and shape descriptors capturing local thickness and surface area dilation were defined for the bilateral accumbens, amygdala, putamen, pallidum, thalamus, caudate, and hippocampus. Regression models adjusting for clinical and demographic variables examined between and within group differences in morphometry associated with HIV. We assessed whether baseline CD4 count and cART status or timing associated with brain maturation within the PaHIV group. All models were adjusted for multiple comparisons using the false discovery rate. A pallidal subregion was significantly thinner in children with PaHIV. Regional thickness, surface area, and volume of the pallidum was associated with CD4 count in children with PaHIV. Longitudinal morphometry was not associated with HIV or cART status or timing, however, the trajectory of the left pallidum volume was positively associated with baseline CD4 count. Our findings corroborate reports in adult cohorts demonstrating a high predilection for HIV-mediated abnormalities in the basal ganglia, but suggest the effect of stable PaHIV infection on morphological aspects of brain development may be subtle. 2019-08-05T04:42:10Z 2019-08-05T04:42:10Z 2019-01-01 Journal 22131582 2-s2.0-85064633801 10.1016/j.nicl.2019.101810 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064633801&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/65843
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Neuroscience
spellingShingle Medicine
Neuroscience
Benjamin S.C. Wade
Victor G. Valcour
Thanyawee Puthanakit
Arvin Saremi
Boris A. Gutman
Talia M. Nir
Christa Watson
Linda Aurpibul
Pope Kosalaraksa
Pradthana Ounchanum
Stephen Kerr
Netsiri Dumrongpisutikul
Pannee Visrutaratna
Jiraporn Srinakarin
Monthana Pothisri
Katherine L. Narr
Paul M. Thompson
Jintanat Ananworanich
Robert H. Paul
Neda Jahanshad
Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV
description © 2019 Alterations in subcortical brain structures have been reported in adults with HIV and, to a lesser extent, pediatric cohorts. The extent of longitudinal structural abnormalities in children with perinatal HIV infection (PaHIV) remains unclear. We modeled subcortical morphometry from whole brain structural magnetic resonance imaging (1.5 T) scans of 43 Thai children with PaHIV (baseline age = 11.09±2.36 years) and 50 HIV− children (11.26±2.80 years) using volumetric and surface-based shape analyses. The PaHIV sample were randomized to initiate combination antiretroviral treatment (cART) when CD4 counts were 15–24% (immediate: n = 22) or when CD4 < 15% (deferred: n = 21). Follow-up scans were acquired approximately 52 weeks after baseline. Volumetric and shape descriptors capturing local thickness and surface area dilation were defined for the bilateral accumbens, amygdala, putamen, pallidum, thalamus, caudate, and hippocampus. Regression models adjusting for clinical and demographic variables examined between and within group differences in morphometry associated with HIV. We assessed whether baseline CD4 count and cART status or timing associated with brain maturation within the PaHIV group. All models were adjusted for multiple comparisons using the false discovery rate. A pallidal subregion was significantly thinner in children with PaHIV. Regional thickness, surface area, and volume of the pallidum was associated with CD4 count in children with PaHIV. Longitudinal morphometry was not associated with HIV or cART status or timing, however, the trajectory of the left pallidum volume was positively associated with baseline CD4 count. Our findings corroborate reports in adult cohorts demonstrating a high predilection for HIV-mediated abnormalities in the basal ganglia, but suggest the effect of stable PaHIV infection on morphological aspects of brain development may be subtle.
format Journal
author Benjamin S.C. Wade
Victor G. Valcour
Thanyawee Puthanakit
Arvin Saremi
Boris A. Gutman
Talia M. Nir
Christa Watson
Linda Aurpibul
Pope Kosalaraksa
Pradthana Ounchanum
Stephen Kerr
Netsiri Dumrongpisutikul
Pannee Visrutaratna
Jiraporn Srinakarin
Monthana Pothisri
Katherine L. Narr
Paul M. Thompson
Jintanat Ananworanich
Robert H. Paul
Neda Jahanshad
author_facet Benjamin S.C. Wade
Victor G. Valcour
Thanyawee Puthanakit
Arvin Saremi
Boris A. Gutman
Talia M. Nir
Christa Watson
Linda Aurpibul
Pope Kosalaraksa
Pradthana Ounchanum
Stephen Kerr
Netsiri Dumrongpisutikul
Pannee Visrutaratna
Jiraporn Srinakarin
Monthana Pothisri
Katherine L. Narr
Paul M. Thompson
Jintanat Ananworanich
Robert H. Paul
Neda Jahanshad
author_sort Benjamin S.C. Wade
title Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV
title_short Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV
title_full Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV
title_fullStr Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV
title_full_unstemmed Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV
title_sort mapping abnormal subcortical neurodevelopment in a cohort of thai children with hiv
publishDate 2019
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064633801&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/65843
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