Anti-inflammatory effect of trans-4-methoxycinnamaldehyde from Etlingera pavieana in LPS-stimulated macrophages mediated through inactivation of NF-κB and JNK/c-Jun signaling pathways and in rat models of acute inflammation

• Main Authors: Klaokwan Srisook, Sakulrat Mankhong, Natthakarn Chiranthanut, Kittiya Kongsamak, Na thanit Kitwiwat, Patsara Tongjurai, Pornpun Aramsangtienchai
• Format: Journal
• Published: 2019
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063748883&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65859
• Institution: Chiang Mai University

© 2019 Elsevier Inc. Trans-4-methoxycinnamaldehyde (MCD) was isolated from the rhizomes of Etlingera pavieana (Pierre ex Gagnep.) R.M.Sm. MCD shows anti-inflammatory effects. However, the molecular mechanism underlying its anti-inflammatory action has not been described. In this study, we investiga...