Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine

• Main Authors: Nurziana Ngah, Nor Azanita Mohamed, Deny Susanti Darnis
• Language: English
• Published: Science Faculty of Chiang Mai University 2019
• Subjects: 2-halobenzoyl thiourea; alanine and antioxidant
• Online Access: http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=6816; http://cmuir.cmu.ac.th/jspui/handle/6653943832/66117
• Institution: Chiang Mai University

Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical values. The FTIR spectra showed the presence of important bands of the compounds while the 1H-NMR and 13C-NMR exhibited the expected chemical shifts. The compounds exerted weak antioxidant activity in DPPH scavenging test and moderate to good activity in β-carotene bleaching test. The inclusion of halogen atoms has facilitated the released of hydrogen atoms and introduction of α- and β-alanine have increased the β-carotene bleaching and DPPH scavenging activities of the compounds.