The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction

• Main Authors: Hyeong Jun Kim, Linda Yen, Somsakul P. Wongpalee, Jessica A. Kirshner, Nicita Mehta, Yan Xue, Jonathan B. Johnston, Alma L. Burlingame, John K. Kim, Joseph J. Loparo, Steve E. Jacobsen
• Format: Journal
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070205888&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/66582
• Institution: Chiang Mai University

© 2019 Elsevier Inc. Microrchidia (MORC) ATPases are critical for gene silencing and chromatin compaction in multiple eukaryotic systems, but the mechanisms by which MORC proteins act are poorly understood. Here, we apply a series of biochemical, single-molecule, and cell-based imaging approaches to...