Kinetic analysis and modelling of enzymatic (R)-phenylacetylcarbinol batch biotransformation process

• Main Authors: Leksawasdi N., Chow Y.Y.S., Breuer M., Hauer B., Rosche B., Rogers P.L.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-3042511903&partnerID=40&md5=354b724077eeba8a250c7a0cb2813112; http://cmuir.cmu.ac.th/handle/6653943832/666
• Institution: Chiang Mai University

Initial rate and biotransformation studies were applied to refine and validate a mathematical model for enzymatic (R)-phenylacetylcarbinol (PAC) production from pyruvate and benzaldehyde using Candida utilis pyruvate decarboxylase (PDC). The rate of PAC formation was directly proportional to the enz...