Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Although coenzyme Q10 (CoQ10) supplementation has shown to reduce pain levels in chronic pain, the effects of CoQ10 supplementation on pain, anxiety, brain activity, mitochondrial oxidative stress, antioxidants, and inflamma...

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Main Authors: Passakorn Sawaddiruk, Nattayaporn Apaijai, Sahattaya Paiboonworachat, Tawika Kaewchur, Nuntana Kasitanon, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Nipon Chattipakorn, Siriporn C. Chattipakorn
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Published: 2019
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/66600
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spelling th-cmuir.6653943832-666002019-09-16T12:48:10Z Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction Passakorn Sawaddiruk Nattayaporn Apaijai Sahattaya Paiboonworachat Tawika Kaewchur Nuntana Kasitanon Thidarat Jaiwongkam Sasiwan Kerdphoo Nipon Chattipakorn Siriporn C. Chattipakorn Biochemistry, Genetics and Molecular Biology © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Although coenzyme Q10 (CoQ10) supplementation has shown to reduce pain levels in chronic pain, the effects of CoQ10 supplementation on pain, anxiety, brain activity, mitochondrial oxidative stress, antioxidants, and inflammation in pregabalin-treated fibromyalgia (FM) patients have not clearly elucidated. We hypothesised that CoQ10 supplementation reduced pain better than pregabalin alone via reducing brain activity, mitochondrial oxidative stress, inflammation, and increasing antioxidant levels in pregabalin-treated FM patients. A double-blind randomised placebo-controlled trial was conducted. Eleven FM patients were enrolled with 2 weeks wash-out then randomly allocated to 2 treatment groups; pregabalin with CoQ10 or pregabalin with placebo for 40 d. Then, patients in CoQ10 group were switched to placebo, and patients in placebo group were switched to CoQ10 for another 40 d. Pain pressure threshold (PPT), FM questionnaire, anxiety, and pain score were examined. Peripheral blood mononuclear cells (PBMCs) were isolated to investigate mitochondrial oxidative stress and inflammation at day 0, 40, and 80. The level of antioxidants and brain positron emission tomography (PET) scan were also determined at these time points. Pregabalin alone reduced pain and anxiety via decreasing brain activity compared with their baseline. However, it did not affect mitochondrial oxidative stress and inflammation. Supplementation with CoQ10 effectively reduced greater pain, anxiety and brain activity, mitochondrial oxidative stress, and inflammation. CoQ10 also increased a reduced glutathione levels and superoxide dismutase (SOD) levels in FM patients. These findings provide new evidence that CoQ10 supplementation provides further benefit for relieving pain sensation in pregabalin-treated FM patients, possibly via improving mitochondrial function, reducing inflammation, and decreasing brain activity. 2019-09-16T12:48:10Z 2019-09-16T12:48:10Z 2019-01-01 Journal 10292470 10715762 2-s2.0-85070505844 10.1080/10715762.2019.1645955 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070505844&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/66600
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Passakorn Sawaddiruk
Nattayaporn Apaijai
Sahattaya Paiboonworachat
Tawika Kaewchur
Nuntana Kasitanon
Thidarat Jaiwongkam
Sasiwan Kerdphoo
Nipon Chattipakorn
Siriporn C. Chattipakorn
Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
description © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Although coenzyme Q10 (CoQ10) supplementation has shown to reduce pain levels in chronic pain, the effects of CoQ10 supplementation on pain, anxiety, brain activity, mitochondrial oxidative stress, antioxidants, and inflammation in pregabalin-treated fibromyalgia (FM) patients have not clearly elucidated. We hypothesised that CoQ10 supplementation reduced pain better than pregabalin alone via reducing brain activity, mitochondrial oxidative stress, inflammation, and increasing antioxidant levels in pregabalin-treated FM patients. A double-blind randomised placebo-controlled trial was conducted. Eleven FM patients were enrolled with 2 weeks wash-out then randomly allocated to 2 treatment groups; pregabalin with CoQ10 or pregabalin with placebo for 40 d. Then, patients in CoQ10 group were switched to placebo, and patients in placebo group were switched to CoQ10 for another 40 d. Pain pressure threshold (PPT), FM questionnaire, anxiety, and pain score were examined. Peripheral blood mononuclear cells (PBMCs) were isolated to investigate mitochondrial oxidative stress and inflammation at day 0, 40, and 80. The level of antioxidants and brain positron emission tomography (PET) scan were also determined at these time points. Pregabalin alone reduced pain and anxiety via decreasing brain activity compared with their baseline. However, it did not affect mitochondrial oxidative stress and inflammation. Supplementation with CoQ10 effectively reduced greater pain, anxiety and brain activity, mitochondrial oxidative stress, and inflammation. CoQ10 also increased a reduced glutathione levels and superoxide dismutase (SOD) levels in FM patients. These findings provide new evidence that CoQ10 supplementation provides further benefit for relieving pain sensation in pregabalin-treated FM patients, possibly via improving mitochondrial function, reducing inflammation, and decreasing brain activity.
format Journal
author Passakorn Sawaddiruk
Nattayaporn Apaijai
Sahattaya Paiboonworachat
Tawika Kaewchur
Nuntana Kasitanon
Thidarat Jaiwongkam
Sasiwan Kerdphoo
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_facet Passakorn Sawaddiruk
Nattayaporn Apaijai
Sahattaya Paiboonworachat
Tawika Kaewchur
Nuntana Kasitanon
Thidarat Jaiwongkam
Sasiwan Kerdphoo
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_sort Passakorn Sawaddiruk
title Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
title_short Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
title_full Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
title_fullStr Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
title_full_unstemmed Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
title_sort coenzyme q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
publishDate 2019
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070505844&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/66600
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