Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition

© 2019 British Society for Neuroendocrinology Lipocalin-2 (LCN2) has been known to play an important role in pathological conditions, specifically in response to inflammation, infection and injury to cells. Recently, several research teams have been interested in investigating its association with c...

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Main Authors: Kanokporn Pinyopornpanish, Nipon Chattipakorn, Siriporn C. Chattipakorn
Format: Journal
Published: 2019
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071315817&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/66602
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-666022019-09-16T12:58:51Z Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition Kanokporn Pinyopornpanish Nipon Chattipakorn Siriporn C. Chattipakorn Biochemistry, Genetics and Molecular Biology Medicine Neuroscience © 2019 British Society for Neuroendocrinology Lipocalin-2 (LCN2) has been known to play an important role in pathological conditions, specifically in response to inflammation, infection and injury to cells. Recently, several research teams have been interested in investigating its association with cognition during the progression of pathology. Previous studies have demonstrated that LCN2 is not correlated with cognitive function under normal physiological conditions, although LCN2 has been negatively associated with cognition and some neuropathologies. Increasing LCN2 production is associated with reduced cognitive performance in a rodent model. However, further studies are needed to explore the potential underlying mechanisms of LCN2 on cognitive dysfunction, as well as its clinical relevance. This review aims to summarise the evidence available from in vitro, in vivo and clinical studies concerning the possible role of LCN2 on cognitive function following the onset of pathological conditions. Any contradictory evidence is also assessed and presented. 2019-09-16T12:48:18Z 2019-09-16T12:48:18Z 2019-01-01 Journal 13652826 09538194 2-s2.0-85071315817 10.1111/jne.12779 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071315817&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/66602
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
Neuroscience
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Neuroscience
Kanokporn Pinyopornpanish
Nipon Chattipakorn
Siriporn C. Chattipakorn
Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition
description © 2019 British Society for Neuroendocrinology Lipocalin-2 (LCN2) has been known to play an important role in pathological conditions, specifically in response to inflammation, infection and injury to cells. Recently, several research teams have been interested in investigating its association with cognition during the progression of pathology. Previous studies have demonstrated that LCN2 is not correlated with cognitive function under normal physiological conditions, although LCN2 has been negatively associated with cognition and some neuropathologies. Increasing LCN2 production is associated with reduced cognitive performance in a rodent model. However, further studies are needed to explore the potential underlying mechanisms of LCN2 on cognitive dysfunction, as well as its clinical relevance. This review aims to summarise the evidence available from in vitro, in vivo and clinical studies concerning the possible role of LCN2 on cognitive function following the onset of pathological conditions. Any contradictory evidence is also assessed and presented.
format Journal
author Kanokporn Pinyopornpanish
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_facet Kanokporn Pinyopornpanish
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_sort Kanokporn Pinyopornpanish
title Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition
title_short Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition
title_full Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition
title_fullStr Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition
title_full_unstemmed Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition
title_sort lipocalin-2: its perspectives in brain pathology and possible roles in cognition
publishDate 2019
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071315817&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/66602
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