Antibacterial carbazole alkaloids from Clausena harmandiana twigs

Three new carbazole alkaloids, harmandianamines A-C (1-3), together with fifteen known compounds (4-18) were isolated from the twigs of Clausena harmandiana. The structures were elucidated by spectroscopic methods, including UV, IR, NMR, and MS. The antibacterial activity against Escherichia coli TI...

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Main Authors: Maneerat W., Phakhodee W., Ritthiwigrom T., Cheenpracha S., Promgool T., Yossathera K., Deachathai S., Laphookhieo S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84863989628&partnerID=40&md5=eb48873dec2f569435895d916f02409c
http://cmuir.cmu.ac.th/handle/6653943832/6661
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-66612014-08-30T03:51:04Z Antibacterial carbazole alkaloids from Clausena harmandiana twigs Maneerat W. Phakhodee W. Ritthiwigrom T. Cheenpracha S. Promgool T. Yossathera K. Deachathai S. Laphookhieo S. Three new carbazole alkaloids, harmandianamines A-C (1-3), together with fifteen known compounds (4-18) were isolated from the twigs of Clausena harmandiana. The structures were elucidated by spectroscopic methods, including UV, IR, NMR, and MS. The antibacterial activity against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466 and methicillin-resistant S. aureus (MRSA) SK1 of some isolated compounds was also evaluated. Compound 6 exhibited significant antibacterial activity against MRSA SK1 with an MIC value of 0.25 μg/mL which higher than that of standard drug, vancomycin (MIC value = 1 μg/mL) whereas compounds 14 and 5 showed strong activity with MIC values of 4 and 8 μg/mL, respectively. Only compound 14 showed strong antibacterial activity against S. aureus TISTR 1466 with an MIC value of 4 μg/mL. © 2012 Elsevier B.V. All rights reserved. 2014-08-30T03:51:04Z 2014-08-30T03:51:04Z 2012 Article 0367326X 10.1016/j.fitote.2012.04.026 FTRPA http://www.scopus.com/inward/record.url?eid=2-s2.0-84863989628&partnerID=40&md5=eb48873dec2f569435895d916f02409c http://cmuir.cmu.ac.th/handle/6653943832/6661 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Three new carbazole alkaloids, harmandianamines A-C (1-3), together with fifteen known compounds (4-18) were isolated from the twigs of Clausena harmandiana. The structures were elucidated by spectroscopic methods, including UV, IR, NMR, and MS. The antibacterial activity against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466 and methicillin-resistant S. aureus (MRSA) SK1 of some isolated compounds was also evaluated. Compound 6 exhibited significant antibacterial activity against MRSA SK1 with an MIC value of 0.25 μg/mL which higher than that of standard drug, vancomycin (MIC value = 1 μg/mL) whereas compounds 14 and 5 showed strong activity with MIC values of 4 and 8 μg/mL, respectively. Only compound 14 showed strong antibacterial activity against S. aureus TISTR 1466 with an MIC value of 4 μg/mL. © 2012 Elsevier B.V. All rights reserved.
format Article
author Maneerat W.
Phakhodee W.
Ritthiwigrom T.
Cheenpracha S.
Promgool T.
Yossathera K.
Deachathai S.
Laphookhieo S.
spellingShingle Maneerat W.
Phakhodee W.
Ritthiwigrom T.
Cheenpracha S.
Promgool T.
Yossathera K.
Deachathai S.
Laphookhieo S.
Antibacterial carbazole alkaloids from Clausena harmandiana twigs
author_facet Maneerat W.
Phakhodee W.
Ritthiwigrom T.
Cheenpracha S.
Promgool T.
Yossathera K.
Deachathai S.
Laphookhieo S.
author_sort Maneerat W.
title Antibacterial carbazole alkaloids from Clausena harmandiana twigs
title_short Antibacterial carbazole alkaloids from Clausena harmandiana twigs
title_full Antibacterial carbazole alkaloids from Clausena harmandiana twigs
title_fullStr Antibacterial carbazole alkaloids from Clausena harmandiana twigs
title_full_unstemmed Antibacterial carbazole alkaloids from Clausena harmandiana twigs
title_sort antibacterial carbazole alkaloids from clausena harmandiana twigs
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84863989628&partnerID=40&md5=eb48873dec2f569435895d916f02409c
http://cmuir.cmu.ac.th/handle/6653943832/6661
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