Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd Purpose: To investigate disorganization of retinal inner layers (DRIL) as a biomarker in eyes with diabetic macular oedema (DME) treated by intravitreal dexamethasone (DEX) implant. Methods: Multicentre, re...

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Main Authors: Dinah Zur, Matias Iglicki, Anna Sala-Puigdollers, Jay Chhablani, Marco Lupidi, Samantha Fraser-Bell, Thais Sousa Mendes, Voraporn Chaikitmongkol, Zafer Cebeci, Dolev Dollberg, Catharina Busch, Alessandro Invernizzi, Zohar Habot-Wilner, Anat Loewenstein
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Published: 2019
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/66733
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spelling th-cmuir.6653943832-667332019-09-16T12:58:41Z Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant Dinah Zur Matias Iglicki Anna Sala-Puigdollers Jay Chhablani Marco Lupidi Samantha Fraser-Bell Thais Sousa Mendes Voraporn Chaikitmongkol Zafer Cebeci Dolev Dollberg Catharina Busch Alessandro Invernizzi Zohar Habot-Wilner Anat Loewenstein Medicine © 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd Purpose: To investigate disorganization of retinal inner layers (DRIL) as a biomarker in eyes with diabetic macular oedema (DME) treated by intravitreal dexamethasone (DEX) implant. Methods: Multicentre, retrospective study including eyes with DME treated with DEX implant and follow-up of 12 months after the first injection. OCT scans were evaluated for the presence of DRIL and other structural features. Best corrected visual acuity (BCVA) and central subfield thickness (CST) were recorded at baseline and at 2, 4, 6 and 12 months after treatment. Correlation between DRIL at baseline and outcomes after DEX treatment and the change in DRIL were analysed. Results: A total of 177 eyes (177 patients; naïve, n = 131; refractory, n = 46) were included. Patients without DRIL at baseline gained significantly more vision and enjoyed greater reduction in CST over 12 months (both p = 0.03). DRIL at the boundary between the ganglion cell-inner plexiform complex and inner nuclear layer improved in 48/64 eyes (75%, p < 0.001), while DRIL between the inner nuclear layer and outer plexiform layer improved in 27/77 eyes (35%, p = 0.004). Conclusions: This is the first study to show that DEX implant has the potential to ameliorate DRIL. Patients without DRIL at baseline have a favourable outcome. DRIL may serve a robust biomarker in DME treated by DEX implant. 2019-09-16T12:58:41Z 2019-09-16T12:58:41Z 2019-01-01 Journal 17553768 1755375X 2-s2.0-85070801941 10.1111/aos.14230 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070801941&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/66733
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Dinah Zur
Matias Iglicki
Anna Sala-Puigdollers
Jay Chhablani
Marco Lupidi
Samantha Fraser-Bell
Thais Sousa Mendes
Voraporn Chaikitmongkol
Zafer Cebeci
Dolev Dollberg
Catharina Busch
Alessandro Invernizzi
Zohar Habot-Wilner
Anat Loewenstein
Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant
description © 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd Purpose: To investigate disorganization of retinal inner layers (DRIL) as a biomarker in eyes with diabetic macular oedema (DME) treated by intravitreal dexamethasone (DEX) implant. Methods: Multicentre, retrospective study including eyes with DME treated with DEX implant and follow-up of 12 months after the first injection. OCT scans were evaluated for the presence of DRIL and other structural features. Best corrected visual acuity (BCVA) and central subfield thickness (CST) were recorded at baseline and at 2, 4, 6 and 12 months after treatment. Correlation between DRIL at baseline and outcomes after DEX treatment and the change in DRIL were analysed. Results: A total of 177 eyes (177 patients; naïve, n = 131; refractory, n = 46) were included. Patients without DRIL at baseline gained significantly more vision and enjoyed greater reduction in CST over 12 months (both p = 0.03). DRIL at the boundary between the ganglion cell-inner plexiform complex and inner nuclear layer improved in 48/64 eyes (75%, p < 0.001), while DRIL between the inner nuclear layer and outer plexiform layer improved in 27/77 eyes (35%, p = 0.004). Conclusions: This is the first study to show that DEX implant has the potential to ameliorate DRIL. Patients without DRIL at baseline have a favourable outcome. DRIL may serve a robust biomarker in DME treated by DEX implant.
format Journal
author Dinah Zur
Matias Iglicki
Anna Sala-Puigdollers
Jay Chhablani
Marco Lupidi
Samantha Fraser-Bell
Thais Sousa Mendes
Voraporn Chaikitmongkol
Zafer Cebeci
Dolev Dollberg
Catharina Busch
Alessandro Invernizzi
Zohar Habot-Wilner
Anat Loewenstein
author_facet Dinah Zur
Matias Iglicki
Anna Sala-Puigdollers
Jay Chhablani
Marco Lupidi
Samantha Fraser-Bell
Thais Sousa Mendes
Voraporn Chaikitmongkol
Zafer Cebeci
Dolev Dollberg
Catharina Busch
Alessandro Invernizzi
Zohar Habot-Wilner
Anat Loewenstein
author_sort Dinah Zur
title Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant
title_short Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant
title_full Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant
title_fullStr Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant
title_full_unstemmed Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant
title_sort disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant
publishDate 2019
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070801941&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/66733
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