Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids

• Main Authors: Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A. Marqués, Cédric Moro, Sophie Laye, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C. Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P. Guiard
• Format: Journal
• Published: 2019
• Subjects: Neuroscience
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070536885&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/66735
• Institution: Chiang Mai University

© 2019 by the authors. All rights reserved. Epidemiological studies indicate that insulin resistance (IR), a hallmark of type 2 diabetes, is associated with an increased risk of major depression. Here, we demonstrated that male mice fed a high-fat diet (HFD) exhibited peripheral metabolic impairment...