Bioactive carbazole alkaloids from Clausena wallichii roots

Bioactive carbazole alkaloids from Clausena wallichii roots

Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus...

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Main Authors: Maneerat W., Ritthiwigrom T., Cheenpracha S., Promgool T., Yossathera K., Deachathai S., Phakhodee W., Laphookhieo S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84860341545&partnerID=40&md5=6d094eb54dca9aa7c26ef0058767a21e
http://cmuir.cmu.ac.th/handle/6653943832/6700
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-67002014-08-30T03:51:07Z Bioactive carbazole alkaloids from Clausena wallichii roots Maneerat W. Ritthiwigrom T. Cheenpracha S. Promgool T. Yossathera K. Deachathai S. Phakhodee W. Laphookhieo S. Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC 50 values of 10.2 and 4.5 μM, respectively. © 2012 The American Chemical Society and American Society of Pharmacognosy. 2014-08-30T03:51:07Z 2014-08-30T03:51:07Z 2012 Article 1633864 10.1021/np3000365 22482432 JNPRD http://www.scopus.com/inward/record.url?eid=2-s2.0-84860341545&partnerID=40&md5=6d094eb54dca9aa7c26ef0058767a21e http://cmuir.cmu.ac.th/handle/6653943832/6700 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC 50 values of 10.2 and 4.5 μM, respectively. © 2012 The American Chemical Society and American Society of Pharmacognosy.
format Article
author Maneerat W.
Ritthiwigrom T.
Cheenpracha S.
Promgool T.
Yossathera K.
Deachathai S.
Phakhodee W.
Laphookhieo S.
spellingShingle Maneerat W.
Ritthiwigrom T.
Cheenpracha S.
Promgool T.
Yossathera K.
Deachathai S.
Phakhodee W.
Laphookhieo S.
Bioactive carbazole alkaloids from Clausena wallichii roots
author_facet Maneerat W.
Ritthiwigrom T.
Cheenpracha S.
Promgool T.
Yossathera K.
Deachathai S.
Phakhodee W.
Laphookhieo S.
author_sort Maneerat W.
title Bioactive carbazole alkaloids from Clausena wallichii roots
title_short Bioactive carbazole alkaloids from Clausena wallichii roots
title_full Bioactive carbazole alkaloids from Clausena wallichii roots
title_fullStr Bioactive carbazole alkaloids from Clausena wallichii roots
title_full_unstemmed Bioactive carbazole alkaloids from Clausena wallichii roots
title_sort bioactive carbazole alkaloids from clausena wallichii roots
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84860341545&partnerID=40&md5=6d094eb54dca9aa7c26ef0058767a21e
http://cmuir.cmu.ac.th/handle/6653943832/6700
_version_ 1681420662872211456

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