Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol

Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol

An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400...

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Main Authors: Rubina Munir, Muhammad Makshoof Atha, Muhammad Zia-ur-Rehman, Noman Javid
Language:English
Published: Science Faculty of Chiang Mai University 2020
Subjects:
quinoline
nucleophilic aromatic substitution
phase transfer catalyst
CTAB
piperidine
Online Access:http://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=10585
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67340
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-673402020-04-02T14:45:04Z Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol Rubina Munir Muhammad Makshoof Atha Muhammad Zia-ur-Rehman Noman Javid quinoline nucleophilic aromatic substitution phase transfer catalyst CTAB piperidine An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400 to obtain the desired products in less reaction time. The newly developed method is found superior to the previously reported methods due to easy work up and excellent yields. 2020-04-02T14:45:04Z 2020-04-02T14:45:04Z 2020 Chiang Mai Journal of Science 47, 1 (January 2020), 175-180 0125-2526 http://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=10585 http://cmuir.cmu.ac.th/jspui/handle/6653943832/67340 Eng Science Faculty of Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
topic quinoline
nucleophilic aromatic substitution
phase transfer catalyst
CTAB
piperidine
spellingShingle quinoline
nucleophilic aromatic substitution
phase transfer catalyst
CTAB
piperidine
Rubina Munir
Muhammad Makshoof Atha
Muhammad Zia-ur-Rehman
Noman Javid
Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
description An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400 to obtain the desired products in less reaction time. The newly developed method is found superior to the previously reported methods due to easy work up and excellent yields.
author Rubina Munir
Muhammad Makshoof Atha
Muhammad Zia-ur-Rehman
Noman Javid
author_facet Rubina Munir
Muhammad Makshoof Atha
Muhammad Zia-ur-Rehman
Noman Javid
author_sort Rubina Munir
title Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
title_short Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
title_full Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
title_fullStr Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
title_full_unstemmed Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
title_sort synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: a facile ctab catalyzed protocol
publisher Science Faculty of Chiang Mai University
publishDate 2020
url http://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=10585
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67340
_version_ 1681426616913231872

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