(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. A new farnesylindole, (R)-3-(8'-hydroxyfarnesyl)-indole (1), as a scalemic mixture (33% ee) along with nine known compounds (2-10), including one farnesylindole, three flavanones, three flavone derivatives and two chalc...

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Main Authors:	Thanika Promchai, Thanaphat Thaima, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Stephen G. Pyne, Thunwadee Limtharakul
Format:	Journal
Published:	2020
Subjects:	Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Chemistry
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076485476&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67569
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-675692020-04-02T15:01:27Z (R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities Thanika Promchai Thanaphat Thaima Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Limtharakul Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Chemistry © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. A new farnesylindole, (R)-3-(8'-hydroxyfarnesyl)-indole (1), as a scalemic mixture (33% ee) along with nine known compounds (2-10), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from Anomianthus dulcis. All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds 1, 2 and 8 showed moderate antiplasmodial activities against TM4/8.Two and K1CB1 strains of which compound 2 displayed the best activity with IC50 values of 27.9 ± 2.57 and 21.4 ± 1.68 µM, respectively. In addition, compound 1 also presented modest cytotoxicity against a KB cell line with an IC50 value of 22.3 ± 0.39 µM. None of these compounds showed cytotoxicity against Vero cells. 2020-04-02T14:55:48Z 2020-04-02T14:55:48Z 2019-01-01 Journal 14786427 14786419 2-s2.0-85076485476 10.1080/14786419.2019.1679139 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076485476&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67569
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Chemistry
spellingShingle	Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Chemistry Thanika Promchai Thanaphat Thaima Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Limtharakul (R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities
description	© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. A new farnesylindole, (R)-3-(8'-hydroxyfarnesyl)-indole (1), as a scalemic mixture (33% ee) along with nine known compounds (2-10), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from Anomianthus dulcis. All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds 1, 2 and 8 showed moderate antiplasmodial activities against TM4/8.Two and K1CB1 strains of which compound 2 displayed the best activity with IC50 values of 27.9 ± 2.57 and 21.4 ± 1.68 µM, respectively. In addition, compound 1 also presented modest cytotoxicity against a KB cell line with an IC50 value of 22.3 ± 0.39 µM. None of these compounds showed cytotoxicity against Vero cells.
format	Journal
author	Thanika Promchai Thanaphat Thaima Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Limtharakul
author_facet	Thanika Promchai Thanaphat Thaima Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Limtharakul
author_sort	Thanika Promchai
title	(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities
title_short	(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities
title_full	(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities
title_fullStr	(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities
title_full_unstemmed	(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities
title_sort	(r)-3-(8'-hydroxyfarnesyl)-indole and other chemical constituents from the flowers of anomianthus dulcis and their antimalarial and cytotoxic activities
publishDate	2020
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076485476&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67569
_version_	1681426659797893120

(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities

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