Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system

© 2019 Krisanapan and Chaiwarith, published by Sciendo. Previous studies showed that clinically significant pathogens were detected within 3 days of incubation using a continuous monitoring automated blood culture instrument. To determine time to blood culture positivity (TTP) of microorganisms usin...

Full description

Saved in:
Bibliographic Details
Main Authors: Pajaree Krisanapan, Romanee Chaiwarith
Format: Journal
Published: 2020
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078206065&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67589
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-67589
record_format dspace
spelling th-cmuir.6653943832-675892020-04-02T14:56:19Z Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system Pajaree Krisanapan Romanee Chaiwarith Biochemistry, Genetics and Molecular Biology © 2019 Krisanapan and Chaiwarith, published by Sciendo. Previous studies showed that clinically significant pathogens were detected within 3 days of incubation using a continuous monitoring automated blood culture instrument. To determine time to blood culture positivity (TTP) of microorganisms using a BD BACTEC™ FX. A cross-sectional study was conducted at Maharaj Nakorn Chiang Mai Hospital, Thailand from October to November 2014. One-hundred and eighty-one patients with 195 episodes of infection and 436 cultures were included in the analysis. Among 181 patients, 55.2% were male and the median age was 61 years (interquartile range (IQR) 50, 76). Of the 195 episodes of infections, the most common source was genitourinary tract (15.4%). Overall, the median TTP was 17 hours (IQR 11.5, 24.5), the shortest TTP was observed in Streptococcus agalactiae. Four-hundred and seventy-eight cultures (97.6%) and all (100%) were detected at 3 days and 5 days of incubation. Factors associated with TTP ≤24 hour were blood drawn from patients who had hematologic malignancy (odds ratio (OR) 9.6, 95% confidence interval (CI) 1.2, 74.3, P = 0.030), endocarditis and vascular infection (OR 8.7, 95% CI 1.1, 67.2, P = 0.038), thrombocytopenia (OR 2.4, 95% CI 1.3, 4.4, P = 0.004), clinical of systemic inflammatory response syndrome (SIRS) (OR 2.3, 95% CI 1.2, 4.5, P = 0.014), and not receiving antimicrobials within 72 hours before cultures taken (OR 2.2, 95% CI 1.4, 3.6, P < 0.001). TTP varied depends upon the pathogens and clinical settings. However, bacteria were isolated from almost, but not all of the blood cultures within 3 days of incubation. 2020-04-02T14:56:19Z 2020-04-02T14:56:19Z 2019-12-19 Journal 1875855X 19057415 2-s2.0-85078206065 10.1515/abm-2019-0041 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078206065&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67589
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Pajaree Krisanapan
Romanee Chaiwarith
Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system
description © 2019 Krisanapan and Chaiwarith, published by Sciendo. Previous studies showed that clinically significant pathogens were detected within 3 days of incubation using a continuous monitoring automated blood culture instrument. To determine time to blood culture positivity (TTP) of microorganisms using a BD BACTEC™ FX. A cross-sectional study was conducted at Maharaj Nakorn Chiang Mai Hospital, Thailand from October to November 2014. One-hundred and eighty-one patients with 195 episodes of infection and 436 cultures were included in the analysis. Among 181 patients, 55.2% were male and the median age was 61 years (interquartile range (IQR) 50, 76). Of the 195 episodes of infections, the most common source was genitourinary tract (15.4%). Overall, the median TTP was 17 hours (IQR 11.5, 24.5), the shortest TTP was observed in Streptococcus agalactiae. Four-hundred and seventy-eight cultures (97.6%) and all (100%) were detected at 3 days and 5 days of incubation. Factors associated with TTP ≤24 hour were blood drawn from patients who had hematologic malignancy (odds ratio (OR) 9.6, 95% confidence interval (CI) 1.2, 74.3, P = 0.030), endocarditis and vascular infection (OR 8.7, 95% CI 1.1, 67.2, P = 0.038), thrombocytopenia (OR 2.4, 95% CI 1.3, 4.4, P = 0.004), clinical of systemic inflammatory response syndrome (SIRS) (OR 2.3, 95% CI 1.2, 4.5, P = 0.014), and not receiving antimicrobials within 72 hours before cultures taken (OR 2.2, 95% CI 1.4, 3.6, P < 0.001). TTP varied depends upon the pathogens and clinical settings. However, bacteria were isolated from almost, but not all of the blood cultures within 3 days of incubation.
format Journal
author Pajaree Krisanapan
Romanee Chaiwarith
author_facet Pajaree Krisanapan
Romanee Chaiwarith
author_sort Pajaree Krisanapan
title Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system
title_short Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system
title_full Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system
title_fullStr Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system
title_full_unstemmed Time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system
title_sort time to blood cultures positivity of microorganisms using a continuous-monitoring automated blood cultures system
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078206065&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67589
_version_ 1681426663485734912