Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice

• Main Authors: Jirapas Sripetchwandee, Juthamas Khamseekaew, Saovaros Svasti, Somdet Srichairatanakool, Suthat Fucharoen, Nipon Chattipakorn, Siriporn C. Chattipakorn
• Format: Journal
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074150815&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/67592
• Institution: Chiang Mai University

© 2019 Elsevier Inc. Aims: We previously demonstrated that iron-overload in non-thalassemic rats induced neurotoxicity and cognitive decline. However, the effect of iron-overload on the brain of thalassemic condition has never been investigated. An iron chelator (deferiprone) provides neuroprotectiv...