Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
© 2019 American Chemical Society and American Society of Pharmacognosy. An ethanolic extract of Anneslea fragrans leaves showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 9.6 μg/mL. Phytochemical investigati...
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th-cmuir.6653943832-676022020-04-02T15:17:19Z Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line Ashraf M. Omar Dya Fita Dibwe Ahmed M. Tawila Sijia Sun Ampai Phrutivorapongkul Suresh Awale Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics © 2019 American Chemical Society and American Society of Pharmacognosy. An ethanolic extract of Anneslea fragrans leaves showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 9.6 μg/mL. Phytochemical investigation of this active extract led to the isolation of two new secondary metabolites, fragranones A (1) and B (2), along with 15 previously reported compounds. The structure elucidation of the new compounds was achieved by HRFABMS, acid hydrolysis, NMR, and ECD spectroscopic analysis. Fragranone A (1) is the first example of a rare natural product bearing an acetonide glucose moiety. Fragranone B (2) is representative of a rare class of natural products with a threonolactone unit linked to a chalcone through an ether linkage. The isolated compounds exhibited antiausterity activity against PANC-1 cells under nutrient-deprived conditions, and betulin (14) was found to be the most potent compound tested, with a PC50 value of 8.4 μM. In addition, fragranone A (1) was found to suppress PANC-1 cancer cell migration in real time. 2020-04-02T14:56:31Z 2020-04-02T14:56:31Z 2019-11-22 Journal 15206025 01633864 2-s2.0-85074785868 10.1021/acs.jnatprod.9b00735 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074785868&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67602 |
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Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Ashraf M. Omar Dya Fita Dibwe Ahmed M. Tawila Sijia Sun Ampai Phrutivorapongkul Suresh Awale Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line |
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© 2019 American Chemical Society and American Society of Pharmacognosy. An ethanolic extract of Anneslea fragrans leaves showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 9.6 μg/mL. Phytochemical investigation of this active extract led to the isolation of two new secondary metabolites, fragranones A (1) and B (2), along with 15 previously reported compounds. The structure elucidation of the new compounds was achieved by HRFABMS, acid hydrolysis, NMR, and ECD spectroscopic analysis. Fragranone A (1) is the first example of a rare natural product bearing an acetonide glucose moiety. Fragranone B (2) is representative of a rare class of natural products with a threonolactone unit linked to a chalcone through an ether linkage. The isolated compounds exhibited antiausterity activity against PANC-1 cells under nutrient-deprived conditions, and betulin (14) was found to be the most potent compound tested, with a PC50 value of 8.4 μM. In addition, fragranone A (1) was found to suppress PANC-1 cancer cell migration in real time. |
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author |
Ashraf M. Omar Dya Fita Dibwe Ahmed M. Tawila Sijia Sun Ampai Phrutivorapongkul Suresh Awale |
author_facet |
Ashraf M. Omar Dya Fita Dibwe Ahmed M. Tawila Sijia Sun Ampai Phrutivorapongkul Suresh Awale |
author_sort |
Ashraf M. Omar |
title |
Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line |
title_short |
Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line |
title_full |
Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line |
title_fullStr |
Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line |
title_full_unstemmed |
Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line |
title_sort |
chemical constituents of anneslea fragrans and their antiausterity activity against the panc-1 human pancreatic cancer cell line |
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2020 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074785868&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67602 |
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