Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line

© 2019 American Chemical Society and American Society of Pharmacognosy. An ethanolic extract of Anneslea fragrans leaves showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 9.6 μg/mL. Phytochemical investigati...

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Main Authors: Ashraf M. Omar, Dya Fita Dibwe, Ahmed M. Tawila, Sijia Sun, Ampai Phrutivorapongkul, Suresh Awale
Format: Journal
Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/67602
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-676022020-04-02T15:17:19Z Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line Ashraf M. Omar Dya Fita Dibwe Ahmed M. Tawila Sijia Sun Ampai Phrutivorapongkul Suresh Awale Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics © 2019 American Chemical Society and American Society of Pharmacognosy. An ethanolic extract of Anneslea fragrans leaves showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 9.6 μg/mL. Phytochemical investigation of this active extract led to the isolation of two new secondary metabolites, fragranones A (1) and B (2), along with 15 previously reported compounds. The structure elucidation of the new compounds was achieved by HRFABMS, acid hydrolysis, NMR, and ECD spectroscopic analysis. Fragranone A (1) is the first example of a rare natural product bearing an acetonide glucose moiety. Fragranone B (2) is representative of a rare class of natural products with a threonolactone unit linked to a chalcone through an ether linkage. The isolated compounds exhibited antiausterity activity against PANC-1 cells under nutrient-deprived conditions, and betulin (14) was found to be the most potent compound tested, with a PC50 value of 8.4 μM. In addition, fragranone A (1) was found to suppress PANC-1 cancer cell migration in real time. 2020-04-02T14:56:31Z 2020-04-02T14:56:31Z 2019-11-22 Journal 15206025 01633864 2-s2.0-85074785868 10.1021/acs.jnatprod.9b00735 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074785868&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67602
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Ashraf M. Omar
Dya Fita Dibwe
Ahmed M. Tawila
Sijia Sun
Ampai Phrutivorapongkul
Suresh Awale
Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
description © 2019 American Chemical Society and American Society of Pharmacognosy. An ethanolic extract of Anneslea fragrans leaves showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 9.6 μg/mL. Phytochemical investigation of this active extract led to the isolation of two new secondary metabolites, fragranones A (1) and B (2), along with 15 previously reported compounds. The structure elucidation of the new compounds was achieved by HRFABMS, acid hydrolysis, NMR, and ECD spectroscopic analysis. Fragranone A (1) is the first example of a rare natural product bearing an acetonide glucose moiety. Fragranone B (2) is representative of a rare class of natural products with a threonolactone unit linked to a chalcone through an ether linkage. The isolated compounds exhibited antiausterity activity against PANC-1 cells under nutrient-deprived conditions, and betulin (14) was found to be the most potent compound tested, with a PC50 value of 8.4 μM. In addition, fragranone A (1) was found to suppress PANC-1 cancer cell migration in real time.
format Journal
author Ashraf M. Omar
Dya Fita Dibwe
Ahmed M. Tawila
Sijia Sun
Ampai Phrutivorapongkul
Suresh Awale
author_facet Ashraf M. Omar
Dya Fita Dibwe
Ahmed M. Tawila
Sijia Sun
Ampai Phrutivorapongkul
Suresh Awale
author_sort Ashraf M. Omar
title Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
title_short Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
title_full Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
title_fullStr Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
title_full_unstemmed Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
title_sort chemical constituents of anneslea fragrans and their antiausterity activity against the panc-1 human pancreatic cancer cell line
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074785868&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67602
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