Proinflammatory effects of IL-1β combined with IL-17A promoted cartilage degradation and suppressed genes associated with cartilage matrix synthesis in vitro

• Main Authors: Patiwat Kongdang, Chatchadawalai Chokchaitaweesuk, Siriwan Tangyuenyong, Siriwan Ongchai
• 格式: 雜誌
• 出版: 2020
• 主題: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073446046&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/67610

© 2019 by the authors. Combinations of IL-1β and other proinflammatory cytokines reportedly promote the severity of arthritis. We aimed to investigate the effects of IL-1β combined with IL-17A on cartilage degradation and synthesis in in vitro models. Cartilage explant degradation was determined usi...