Statins & risk of Clostridium difficile infection: A meta-analysis
© 2019 Indian Journal of Medical Research. Background & objectives: Clostridium difficile infection is one of the most common healthcare-associated infections worldwide. Recent epidemiologic studies have suggested that statin users may have a lower risk of C. difficile infection, although the re...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Journal |
Published: |
2020
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075942372&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67613 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-67613 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-676132020-04-02T14:56:40Z Statins & risk of Clostridium difficile infection: A meta-analysis Karn Wijarnpreecha Panadeekarn Panjawatanan Charat Thongprayoon Patompong Ungprasert Biochemistry, Genetics and Molecular Biology © 2019 Indian Journal of Medical Research. Background & objectives: Clostridium difficile infection is one of the most common healthcare-associated infections worldwide. Recent epidemiologic studies have suggested that statin users may have a lower risk of C. difficile infection, although the results are inconsistent. This meta-analysis was conducted with the aim of summarizing all available data to assess the risk of C. difficile infection among statin users versus non-users. Methods: A literature review was performed using the MEDLINE and EMBASE databases from inception to October 2017. Cohort, case-control and cross-sectional studies that compared the risk of C. difficile infection among statin users versus non-users were included. Pooled odds ratio (OR) and 95 per cent confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Six case-control studies and two cross-sectional studies met the eligibility criteria and were included in this meta-analysis. The risk of C. difficile infection among statin users was significantly lower than non-users with the pooled OR of 0.74 (95% CI, 0.61-0.89). The statistical heterogeneity of this study was high (I[2]=90%). Interpretation & conclusions: This meta-analysis demonstrated a decreased risk of C. difficile infection among statin users versus non-users. Further studies are required to clarify the role of statins for prevention of C. difficile infection in clinical practice. 2020-04-02T14:56:40Z 2020-04-02T14:56:40Z 2019-10-01 Journal 09715916 2-s2.0-85075942372 10.4103/ijmr.IJMR_1973_17 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075942372&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67613 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Biochemistry, Genetics and Molecular Biology |
spellingShingle |
Biochemistry, Genetics and Molecular Biology Karn Wijarnpreecha Panadeekarn Panjawatanan Charat Thongprayoon Patompong Ungprasert Statins & risk of Clostridium difficile infection: A meta-analysis |
description |
© 2019 Indian Journal of Medical Research. Background & objectives: Clostridium difficile infection is one of the most common healthcare-associated infections worldwide. Recent epidemiologic studies have suggested that statin users may have a lower risk of C. difficile infection, although the results are inconsistent. This meta-analysis was conducted with the aim of summarizing all available data to assess the risk of C. difficile infection among statin users versus non-users. Methods: A literature review was performed using the MEDLINE and EMBASE databases from inception to October 2017. Cohort, case-control and cross-sectional studies that compared the risk of C. difficile infection among statin users versus non-users were included. Pooled odds ratio (OR) and 95 per cent confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Six case-control studies and two cross-sectional studies met the eligibility criteria and were included in this meta-analysis. The risk of C. difficile infection among statin users was significantly lower than non-users with the pooled OR of 0.74 (95% CI, 0.61-0.89). The statistical heterogeneity of this study was high (I[2]=90%). Interpretation & conclusions: This meta-analysis demonstrated a decreased risk of C. difficile infection among statin users versus non-users. Further studies are required to clarify the role of statins for prevention of C. difficile infection in clinical practice. |
format |
Journal |
author |
Karn Wijarnpreecha Panadeekarn Panjawatanan Charat Thongprayoon Patompong Ungprasert |
author_facet |
Karn Wijarnpreecha Panadeekarn Panjawatanan Charat Thongprayoon Patompong Ungprasert |
author_sort |
Karn Wijarnpreecha |
title |
Statins & risk of Clostridium difficile infection: A meta-analysis |
title_short |
Statins & risk of Clostridium difficile infection: A meta-analysis |
title_full |
Statins & risk of Clostridium difficile infection: A meta-analysis |
title_fullStr |
Statins & risk of Clostridium difficile infection: A meta-analysis |
title_full_unstemmed |
Statins & risk of Clostridium difficile infection: A meta-analysis |
title_sort |
statins & risk of clostridium difficile infection: a meta-analysis |
publishDate |
2020 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075942372&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67613 |
_version_ |
1681426667900239872 |