Synthesis and iron coordination properties of schizokinen and its imide derivative
This journal is © The Royal Society of Chemistry. The iron(iii) affinity constants for schizokinen and its imide derivative are reported for the first time. Surprisingly, schizokinen possesses a higher affinity for iron(iii) than desferrioxamine B; log KFeIII (FeL), 36.2 and 30.6, respectively. This...
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| Main Authors: | , , , , |
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| Format: | Journal |
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2020
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075692395&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67686 |
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| Institution: | Chiang Mai University |
| Summary: | This journal is © The Royal Society of Chemistry. The iron(iii) affinity constants for schizokinen and its imide derivative are reported for the first time. Surprisingly, schizokinen possesses a higher affinity for iron(iii) than desferrioxamine B; log KFeIII (FeL), 36.2 and 30.6, respectively. This increase in value is associated with the substitution of one hydroxamate function by an α-hydroxycarboxylate grouping. By virtue of the similarity of siderophore-iron(iii) complexes and siderophore-gallium(iii) complexes, schizokinen (which is a Gram positive siderophore) has potential for 68Ga PET-based imaging. |
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