A zein coacervate biomaterial and its time-dependant behaviour

© 2019 Elsevier Ltd. All rights reserved. Zein is a corn-derived protein which has potential as a biomaterial for use in bone surgery. A zein coacervate, in the form of a visco-elastic solid, is proposed for use in other bone-related applications. Unlike other low-cost natural-derived materials such...

Full description

Saved in:
Bibliographic Details
Main Authors: Timothy Quek, Wassanai Wattanutchariya
Format: Conference Proceeding
Published: 2020
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072385476&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67888
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-67888
record_format dspace
spelling th-cmuir.6653943832-678882020-04-02T15:09:59Z A zein coacervate biomaterial and its time-dependant behaviour Timothy Quek Wassanai Wattanutchariya Materials Science © 2019 Elsevier Ltd. All rights reserved. Zein is a corn-derived protein which has potential as a biomaterial for use in bone surgery. A zein coacervate, in the form of a visco-elastic solid, is proposed for use in other bone-related applications. Unlike other low-cost natural-derived materials such as chitosan and gelatin, zein is insoluble in water. This enables it to perform as a substitute for bone wax, as well as a bone filler which undergoes slow degradation. Two methods for producing the non-adhesive resinous substance are described: either directly through adding zein powder into an ethanol-water solution, or indirectly through dissolving zein into solution before coacervation upon further addition of water. Zein coacervate samples are then analysed for changes in properties with time. Loss of mass from the resinous substance is attributed to the evaporation of ethanol and water; this was measured for up for 20 minutes. Rheometeric stress sweeps performed at 0, 10, and 20 minutes after its preparation indicate that the visco-elastic material became harder with time, and more force would be required to deform the material. Finally, in vitro degradation was carried out by immersing zein samples in fluid containing lysozyme. The results suggest that the zein coacervate may be easily manipulated for up until about 10 minutes after preparation, and would degrade in vivo within a matter of weeks. 2020-04-02T15:09:59Z 2020-04-02T15:09:59Z 2019-01-01 Conference Proceeding 22147853 2-s2.0-85072385476 10.1016/j.matpr.2019.06.070 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072385476&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/67888
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Materials Science
spellingShingle Materials Science
Timothy Quek
Wassanai Wattanutchariya
A zein coacervate biomaterial and its time-dependant behaviour
description © 2019 Elsevier Ltd. All rights reserved. Zein is a corn-derived protein which has potential as a biomaterial for use in bone surgery. A zein coacervate, in the form of a visco-elastic solid, is proposed for use in other bone-related applications. Unlike other low-cost natural-derived materials such as chitosan and gelatin, zein is insoluble in water. This enables it to perform as a substitute for bone wax, as well as a bone filler which undergoes slow degradation. Two methods for producing the non-adhesive resinous substance are described: either directly through adding zein powder into an ethanol-water solution, or indirectly through dissolving zein into solution before coacervation upon further addition of water. Zein coacervate samples are then analysed for changes in properties with time. Loss of mass from the resinous substance is attributed to the evaporation of ethanol and water; this was measured for up for 20 minutes. Rheometeric stress sweeps performed at 0, 10, and 20 minutes after its preparation indicate that the visco-elastic material became harder with time, and more force would be required to deform the material. Finally, in vitro degradation was carried out by immersing zein samples in fluid containing lysozyme. The results suggest that the zein coacervate may be easily manipulated for up until about 10 minutes after preparation, and would degrade in vivo within a matter of weeks.
format Conference Proceeding
author Timothy Quek
Wassanai Wattanutchariya
author_facet Timothy Quek
Wassanai Wattanutchariya
author_sort Timothy Quek
title A zein coacervate biomaterial and its time-dependant behaviour
title_short A zein coacervate biomaterial and its time-dependant behaviour
title_full A zein coacervate biomaterial and its time-dependant behaviour
title_fullStr A zein coacervate biomaterial and its time-dependant behaviour
title_full_unstemmed A zein coacervate biomaterial and its time-dependant behaviour
title_sort zein coacervate biomaterial and its time-dependant behaviour
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072385476&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67888
_version_ 1681426718409097216