Reliability and validity of the Thai Drug Hypersensitivity Quality of Life Questionnaire: a multi-center study

• Main Authors: Yuda Chongpison, Pawinee Rerknimitr, Cameron Hurst, Pungjai Mongkolpathumrat, Sirinoot Palapinyo, Leena Chularojanamontri, Yuttana Srinoulprasert, Ticha Rerkpattanapipat, Kumutnart Chanprapaph, Wareeporn Disphanurat, Panlop Chakkavittumrong, Napatra Tovanabutra, Chutika Srisuttiyakorn, Chonlaphat Sukasem, Papapit Tuchinda, Ilaria Baiardini, Jettanong Klaewsongkram
• Format: Journal
• Published: 2020
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074626002&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/67976
• Institution: Chiang Mai University

© 2018 The Author(s) 2018. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. Objective: To adapted the Drug Hypersensitivity Quality of Life (DrHy-Q) Questionnaire from Italian into Thai and assessed its validity and reliability. Design: Prospectively recruited during January 2012-May 2017. Setting: Multicenter; six Thai tertiary university hospitals. Study Participants: Total of 306 patients with physician-diagnosed drug hypersensitivity. Interventions: Internal consistency and test-retest reliability were evaluated among 68 participants using Cronbach's ? and intra-class correlation coefficient (ICC). The validity of Thai DrHy-Q was assessed among 306 participants who completed World Health Organization Quality of Life-BREF (WHOQOL-BREF-THAI). Construct and divergent validities were assessed for Thai DrHy-Q. Known-groups validity assessing discriminating ability was conducted in Thai DrHy-Q and WHOQOL-BREF-THAI. Main outcome measures: Validity; reliability; single vs. multiple drug allergy; non-severe cutaneous adverse reactions (SCAR) vs. SCAR. Results: Thai DrHy-Q showed good reliability (Cronbach's ? = 0.94 and ICC = 0.8). Unidimensional factor structure was established by confirmatory factor analysis (CFI&TLI = 0.999, RMSEA = 0.02). Divergent validity was confirmed by weak correlation between Thai DrHy-Q and WHOQOL-BREF-THAI domains (Pearson's r = -0.41 to -0.19). Known-groups validity of Thai DrHy-Q was confirmed with significant difference between patients with and without life-threatening SCAR (P = 0.02) and patients with multiple implicated drug classes vs. those with one class (P < 0.01); while WHOQOL-BREF-THAI could differentiate presence of life-threatening SCAR (P < 0.01) but not multiple-drug allergy. Conclusions: Thai DrHy-Q was reliable and valid in evaluating quality of life among patients with drug hypersensitivity. Thai DrHy-Q was able to discriminate serious drug allergy phenotypes from non-serious manifestations in clinical practice and capture more specific drug-hypersensitivity aspects than WHOQOL-BREF-THAI.