The effect of metformin and P38 MAPK inhibitor on diabetic bone porosity in non-obese type 2 diabetic rats

• Main Authors: Punyanuch Adulyaritthikul, Jantira Sanit, Nuttikarn Nokkaew, Kantapich Kongpol, Podsawee Mongkolpathumrat, Sakarat na Lampang, Catleya Rojviriya, Sarawut Kumphune
• Format: Journal
• Published: 2020
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075655804&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/67977
• Institution: Chiang Mai University

© 2019 Punyanuch Adulyaritthikul et al. Hyperglycemia enhances bone resorption and impairment. Controlling blood glucose via metformin benefits bone cells. Hyperglycemia enhances basal phosphorylation of p38 mitogen-activated protein kinase (MAPK), which aggravates bone resorption. Therefore, the ai...