Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum

© 2019, CMU J. Nat. Sci. The objectives of this study were to evaluate the anti-inflammatory, analgesic, and antipyretic activities of water extract from fresh leaves of Pseuderanthemum palatiferum (WEPP).The anti-inflammatory activity of WEPP was evaluated in ethylphenylpropiolate (EPP)-induced ear...

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Main Authors: Kannika Inchab, Parirat Khonsung, Natthakarn Chiranthanut, Puongtip Kunanusorn, Ampai Panthong, Seewaboon Sireeratawong
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Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/68130
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-681302020-04-02T15:21:12Z Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum Kannika Inchab Parirat Khonsung Natthakarn Chiranthanut Puongtip Kunanusorn Ampai Panthong Seewaboon Sireeratawong Multidisciplinary © 2019, CMU J. Nat. Sci. The objectives of this study were to evaluate the anti-inflammatory, analgesic, and antipyretic activities of water extract from fresh leaves of Pseuderanthemum palatiferum (WEPP).The anti-inflammatory activity of WEPP was evaluated in ethylphenylpropiolate (EPP)-induced ear edema, carrageenan-induced paw edema, arachidonic acid (AA)-induced paw edema, and cotton pellet-induced granuloma experiments. Acetic acid-induced writhing and tail-flick experiments were conducted to evaluate analgesic activity. Finally, antipyretic activity was evaluated in yeast-induced hyperthermia model. WEPP showed the anti-inflammatory activity and the analgesic activity but without antipyretic property. WEPP (2 mg/ear) significantly inhibited edema thickness induced by EPP (75%). Oral administration of WEPP (600 mg/kg) significantly inhibited paw edema induced by carrageenan (57%), and arachidonic acid (47%). WEPP (600 mg/kg) did not significantly reduce the transudative weight, granuloma weight, and alkaline phosphatase activity in cotton pellet-induced granuloma formation model. The anti-inflammatory property of WEPP demonstrated on the acute phase and not on the chronic phase of inflammation. WEPP oral administration (150, 300, and 600 mg/kg) significantly reduced the writhing response induced by acetic acid by 21%, 57%, and 79%, respectively. In tail-flick test, WEPP slightly increased the reaction time of rats (25%). The analgesic activity of WEPP may act via peripheral pathway. The antipyretic effect of WEPP (600 mg/kg) was not observed in yeast-induced hyperthermia model. WEPP displays an anti-inflammatory effect and has a prominent analgesic effect on the peripheral system. 2020-04-02T15:21:12Z 2020-04-02T15:21:12Z 2019-07-01 Journal 16851994 2-s2.0-85074222976 10.12982/CMUJNS.2019.0027 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074222976&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68130
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Kannika Inchab
Parirat Khonsung
Natthakarn Chiranthanut
Puongtip Kunanusorn
Ampai Panthong
Seewaboon Sireeratawong
Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum
description © 2019, CMU J. Nat. Sci. The objectives of this study were to evaluate the anti-inflammatory, analgesic, and antipyretic activities of water extract from fresh leaves of Pseuderanthemum palatiferum (WEPP).The anti-inflammatory activity of WEPP was evaluated in ethylphenylpropiolate (EPP)-induced ear edema, carrageenan-induced paw edema, arachidonic acid (AA)-induced paw edema, and cotton pellet-induced granuloma experiments. Acetic acid-induced writhing and tail-flick experiments were conducted to evaluate analgesic activity. Finally, antipyretic activity was evaluated in yeast-induced hyperthermia model. WEPP showed the anti-inflammatory activity and the analgesic activity but without antipyretic property. WEPP (2 mg/ear) significantly inhibited edema thickness induced by EPP (75%). Oral administration of WEPP (600 mg/kg) significantly inhibited paw edema induced by carrageenan (57%), and arachidonic acid (47%). WEPP (600 mg/kg) did not significantly reduce the transudative weight, granuloma weight, and alkaline phosphatase activity in cotton pellet-induced granuloma formation model. The anti-inflammatory property of WEPP demonstrated on the acute phase and not on the chronic phase of inflammation. WEPP oral administration (150, 300, and 600 mg/kg) significantly reduced the writhing response induced by acetic acid by 21%, 57%, and 79%, respectively. In tail-flick test, WEPP slightly increased the reaction time of rats (25%). The analgesic activity of WEPP may act via peripheral pathway. The antipyretic effect of WEPP (600 mg/kg) was not observed in yeast-induced hyperthermia model. WEPP displays an anti-inflammatory effect and has a prominent analgesic effect on the peripheral system.
format Journal
author Kannika Inchab
Parirat Khonsung
Natthakarn Chiranthanut
Puongtip Kunanusorn
Ampai Panthong
Seewaboon Sireeratawong
author_facet Kannika Inchab
Parirat Khonsung
Natthakarn Chiranthanut
Puongtip Kunanusorn
Ampai Panthong
Seewaboon Sireeratawong
author_sort Kannika Inchab
title Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum
title_short Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum
title_full Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum
title_fullStr Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum
title_full_unstemmed Evaluation of anti-inflammatory, analgesic, and antipyretic activities of Pseuderanthemum palatiferum
title_sort evaluation of anti-inflammatory, analgesic, and antipyretic activities of pseuderanthemum palatiferum
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074222976&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68130
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