Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study
© 2019 The Author(s). Objective: Age-associated decline in central cholinergic activity makes older adults susceptible to harmful effects of anticholinergics (ACs). Evidence exists of an association between effects of AC medications on cognition. This retrospective cohort study examines how ACs affe...
Saved in:
Main Authors: | , , , , , , |
---|---|
Format: | Journal |
Published: |
2020
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077387029&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68251 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-68251 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-682512020-04-02T15:23:47Z Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study Rewadee Jenraumjit Surarong Chinwong Dujrudee Chinwong Tipaporn Kanjanarach Thanat Kshetradat Tinakon Wongpakaran Nahathai Wongpakaran Biochemistry, Genetics and Molecular Biology © 2019 The Author(s). Objective: Age-associated decline in central cholinergic activity makes older adults susceptible to harmful effects of anticholinergics (ACs). Evidence exists of an association between effects of AC medications on cognition. This retrospective cohort study examines how ACs affect cognition among older adults with Alzheimer's disease (AD) who received acetylcholine esterase inhibitors (AChEIs) over the course of 12 months. Results: A total of 133 (80% women, mean age 78.38 years, SD 7.4) were recruited. No difference in sex, age and comorbid diseases was observed between participants who took ACs, benzodiazepines (BZDs) and AChEIs. The most common prescribed ACs was quetiapine, being used for behavioral and psychological symptoms (BPSD). Multilevel analysis showed that the change of mental state examination scores were significantly predicted in the group using ACs (t (169), - 2.52, p =.020) but not with the groups using BZD (t (162), 0.84, p =.440). Evidence showed that older adults with Alzheimer's disease and exposed to ACs exhibited lower global cognitive scores than those without AC exposure. Using ACs could be a trade-off between controlling BPSD and aggravating cognitive impairment. Highlighting the awareness of the potential anticholinergic effect is important and may be the best policy. 2020-04-02T15:23:47Z 2020-04-02T15:23:47Z 2020-01-02 Journal 17560500 2-s2.0-85077387029 10.1186/s13104-019-4874-z https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077387029&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68251 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Biochemistry, Genetics and Molecular Biology |
spellingShingle |
Biochemistry, Genetics and Molecular Biology Rewadee Jenraumjit Surarong Chinwong Dujrudee Chinwong Tipaporn Kanjanarach Thanat Kshetradat Tinakon Wongpakaran Nahathai Wongpakaran Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study |
description |
© 2019 The Author(s). Objective: Age-associated decline in central cholinergic activity makes older adults susceptible to harmful effects of anticholinergics (ACs). Evidence exists of an association between effects of AC medications on cognition. This retrospective cohort study examines how ACs affect cognition among older adults with Alzheimer's disease (AD) who received acetylcholine esterase inhibitors (AChEIs) over the course of 12 months. Results: A total of 133 (80% women, mean age 78.38 years, SD 7.4) were recruited. No difference in sex, age and comorbid diseases was observed between participants who took ACs, benzodiazepines (BZDs) and AChEIs. The most common prescribed ACs was quetiapine, being used for behavioral and psychological symptoms (BPSD). Multilevel analysis showed that the change of mental state examination scores were significantly predicted in the group using ACs (t (169), - 2.52, p =.020) but not with the groups using BZD (t (162), 0.84, p =.440). Evidence showed that older adults with Alzheimer's disease and exposed to ACs exhibited lower global cognitive scores than those without AC exposure. Using ACs could be a trade-off between controlling BPSD and aggravating cognitive impairment. Highlighting the awareness of the potential anticholinergic effect is important and may be the best policy. |
format |
Journal |
author |
Rewadee Jenraumjit Surarong Chinwong Dujrudee Chinwong Tipaporn Kanjanarach Thanat Kshetradat Tinakon Wongpakaran Nahathai Wongpakaran |
author_facet |
Rewadee Jenraumjit Surarong Chinwong Dujrudee Chinwong Tipaporn Kanjanarach Thanat Kshetradat Tinakon Wongpakaran Nahathai Wongpakaran |
author_sort |
Rewadee Jenraumjit |
title |
Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study |
title_short |
Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study |
title_full |
Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study |
title_fullStr |
Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study |
title_full_unstemmed |
Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: A 1 year follow-up study |
title_sort |
anticholinergics and benzodiazepines on cognitive impairment among elderly with alzheimer's disease: a 1 year follow-up study |
publishDate |
2020 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077387029&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68251 |
_version_ |
1681426785808416768 |