Renal Lipid Metabolism and Lipotoxicity in Diabetes

© 2019 Southern Society for Clinical Investigation The pathogenesis of diabetic kidney disease is a complex process caused by both glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid deposition is found in both tubular and glomerular portions of the kidneys,...

Full description

Saved in:
Bibliographic Details
Main Authors: Laongdao Thongnak, Anchalee Pongchaidecha, Anusorn Lungkaphin
Format: Journal
Published: 2020
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078561136&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68490
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-68490
record_format dspace
spelling th-cmuir.6653943832-684902020-04-02T15:28:18Z Renal Lipid Metabolism and Lipotoxicity in Diabetes Laongdao Thongnak Anchalee Pongchaidecha Anusorn Lungkaphin Medicine © 2019 Southern Society for Clinical Investigation The pathogenesis of diabetic kidney disease is a complex process caused by both glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid deposition is found in both tubular and glomerular portions of the kidneys, which are the major sites of diabetic nephropathy lesions. The aim of this review was to provide insights into the mechanisms that lead to the development of renal lipid accumulation and the effects of renal lipotoxicity in the diabetic condition. An increased number of lipogenic genes and a decreased number of lipid oxidation genes are also detected in diabetic kidneys, both of which lead to lipid accumulation. The induction of oxidative stress, inflammation, fibrosis and apoptosis caused by lipid accumulation and lipid metabolites is called lipotoxicity. Renal lipotoxicity due to derangement in lipid metabolism may be a pathogenic mechanism leading to diabetic nephropathy and renal dysfunction. 2020-04-02T15:28:18Z 2020-04-02T15:28:18Z 2020-02-01 Journal 15382990 00029629 2-s2.0-85078561136 10.1016/j.amjms.2019.11.004 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078561136&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68490
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Laongdao Thongnak
Anchalee Pongchaidecha
Anusorn Lungkaphin
Renal Lipid Metabolism and Lipotoxicity in Diabetes
description © 2019 Southern Society for Clinical Investigation The pathogenesis of diabetic kidney disease is a complex process caused by both glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid deposition is found in both tubular and glomerular portions of the kidneys, which are the major sites of diabetic nephropathy lesions. The aim of this review was to provide insights into the mechanisms that lead to the development of renal lipid accumulation and the effects of renal lipotoxicity in the diabetic condition. An increased number of lipogenic genes and a decreased number of lipid oxidation genes are also detected in diabetic kidneys, both of which lead to lipid accumulation. The induction of oxidative stress, inflammation, fibrosis and apoptosis caused by lipid accumulation and lipid metabolites is called lipotoxicity. Renal lipotoxicity due to derangement in lipid metabolism may be a pathogenic mechanism leading to diabetic nephropathy and renal dysfunction.
format Journal
author Laongdao Thongnak
Anchalee Pongchaidecha
Anusorn Lungkaphin
author_facet Laongdao Thongnak
Anchalee Pongchaidecha
Anusorn Lungkaphin
author_sort Laongdao Thongnak
title Renal Lipid Metabolism and Lipotoxicity in Diabetes
title_short Renal Lipid Metabolism and Lipotoxicity in Diabetes
title_full Renal Lipid Metabolism and Lipotoxicity in Diabetes
title_fullStr Renal Lipid Metabolism and Lipotoxicity in Diabetes
title_full_unstemmed Renal Lipid Metabolism and Lipotoxicity in Diabetes
title_sort renal lipid metabolism and lipotoxicity in diabetes
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078561136&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68490
_version_ 1681426829395623936