Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients

© 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd Aims: To investigate susceptible human leukocyte antigen (HLA) alleles and their associations with clinical features in Thai patients with Behçet's disease (BD). Method: Eighteen HLA-A and 36...

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Main Authors: Worawit Louthrenoo, Nuntana Kasitanon, Kessara Pathanapitoon, Suparaporn Wangkaew, Shoji Kuwata, Ai Nishi, Toshikatsu Kaburaki, Rie Tanaka, Fujio Takeuchi
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Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/68497
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spelling th-cmuir.6653943832-684972020-04-02T15:28:30Z Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients Worawit Louthrenoo Nuntana Kasitanon Kessara Pathanapitoon Suparaporn Wangkaew Shoji Kuwata Ai Nishi Toshikatsu Kaburaki Rie Tanaka Fujio Takeuchi Medicine © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd Aims: To investigate susceptible human leukocyte antigen (HLA) alleles and their associations with clinical features in Thai patients with Behçet's disease (BD). Method: Eighteen HLA-A and 36 HLA-B alleles were determined in 42 Thai BD patients and 99 healthy controls (HCs) by reverse line blot assay, and reconfirmed by MICRO SSP assay. Results: The BD patients had significantly higher allele frequency (AF) of HLA-B*51 than the HCs (13.10% vs 5.05%, P =.025). The AF of HLA-A*26, -A*26:01 and -B*51:01 also was higher and almost reached statistical significance (5.59% vs 1.52%, P =.054, 5.95% vs 1.52%, P =.054 and 10.71% vs 4.04%, P =.051, respectively). However, the BD patients had significantly higher AF of either HLA-A*26:01 or -B*51:01 (16.67% vs 5.56%, P =.005), or -A*26:01 or -B*51X (19.05% vs 6.56%, P =.003). The AF of HLA-B*51:01 and -B*51X increased significantly in -A*26:01 non-carrier BD patients (12.16% vs 4.17%, P =.024 and 14.86% vs 5.21%, P =.019, respectively); and that of HLA-A*26:01 was significantly higher in -B*51X non-carrier BD patients (7.58% vs 1.67%, P =.034). HLA-B*51:01 associated significantly with the presence of posterior uveitis and visual impairment (18.18% vs 2.50%, P =.031 for both conditions). HLA-B*51:01 was not observed in BD patients with gastrointestinal involvement or arthritis. Furthermore, the AF of HLA-B*51:01 was significantly higher in HLA-A*26:01 non-carrier BD patients without arthritis (17.30% vs 0%, P =.050). Conclusion: HLA-B*51:01 was a susceptible allele for Thai BD patients, and associated with posterior uveitis and visual impairment. HLA-A*26:01 was another susceptible allele in HLA-B*51X non-carrier patients. The protective effect of HLA-B*51:01 on arthritis needs further investigation. 2020-04-02T15:28:30Z 2020-04-02T15:28:30Z 2020-02-01 Journal 1756185X 17561841 2-s2.0-85078020983 10.1111/1756-185X.13785 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078020983&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68497
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Worawit Louthrenoo
Nuntana Kasitanon
Kessara Pathanapitoon
Suparaporn Wangkaew
Shoji Kuwata
Ai Nishi
Toshikatsu Kaburaki
Rie Tanaka
Fujio Takeuchi
Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients
description © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd Aims: To investigate susceptible human leukocyte antigen (HLA) alleles and their associations with clinical features in Thai patients with Behçet's disease (BD). Method: Eighteen HLA-A and 36 HLA-B alleles were determined in 42 Thai BD patients and 99 healthy controls (HCs) by reverse line blot assay, and reconfirmed by MICRO SSP assay. Results: The BD patients had significantly higher allele frequency (AF) of HLA-B*51 than the HCs (13.10% vs 5.05%, P =.025). The AF of HLA-A*26, -A*26:01 and -B*51:01 also was higher and almost reached statistical significance (5.59% vs 1.52%, P =.054, 5.95% vs 1.52%, P =.054 and 10.71% vs 4.04%, P =.051, respectively). However, the BD patients had significantly higher AF of either HLA-A*26:01 or -B*51:01 (16.67% vs 5.56%, P =.005), or -A*26:01 or -B*51X (19.05% vs 6.56%, P =.003). The AF of HLA-B*51:01 and -B*51X increased significantly in -A*26:01 non-carrier BD patients (12.16% vs 4.17%, P =.024 and 14.86% vs 5.21%, P =.019, respectively); and that of HLA-A*26:01 was significantly higher in -B*51X non-carrier BD patients (7.58% vs 1.67%, P =.034). HLA-B*51:01 associated significantly with the presence of posterior uveitis and visual impairment (18.18% vs 2.50%, P =.031 for both conditions). HLA-B*51:01 was not observed in BD patients with gastrointestinal involvement or arthritis. Furthermore, the AF of HLA-B*51:01 was significantly higher in HLA-A*26:01 non-carrier BD patients without arthritis (17.30% vs 0%, P =.050). Conclusion: HLA-B*51:01 was a susceptible allele for Thai BD patients, and associated with posterior uveitis and visual impairment. HLA-A*26:01 was another susceptible allele in HLA-B*51X non-carrier patients. The protective effect of HLA-B*51:01 on arthritis needs further investigation.
format Journal
author Worawit Louthrenoo
Nuntana Kasitanon
Kessara Pathanapitoon
Suparaporn Wangkaew
Shoji Kuwata
Ai Nishi
Toshikatsu Kaburaki
Rie Tanaka
Fujio Takeuchi
author_facet Worawit Louthrenoo
Nuntana Kasitanon
Kessara Pathanapitoon
Suparaporn Wangkaew
Shoji Kuwata
Ai Nishi
Toshikatsu Kaburaki
Rie Tanaka
Fujio Takeuchi
author_sort Worawit Louthrenoo
title Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients
title_short Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients
title_full Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients
title_fullStr Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients
title_full_unstemmed Contribution of HLA-B*51:01 and -A*26:01 to Behçet's disease and their clinical association in Thai patients
title_sort contribution of hla-b*51:01 and -a*26:01 to behçet's disease and their clinical association in thai patients
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078020983&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68497
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