Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions

© 2019 Elsevier Inc. Chemotherapy has significantly increased the number of cancer survivors. However, chemotherapy itself carries various adverse effects that limit the efficacy of treatment and quality of life of the cancer patients. Most patients who have received chemotherapy report some cogniti...

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Main Authors: Benjamin Ongnok, Nipon Chattipakorn, Siriporn C. Chattipakorn
Format: Journal
Published: 2020
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075263290&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68554
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-685542020-04-02T15:29:23Z Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions Benjamin Ongnok Nipon Chattipakorn Siriporn C. Chattipakorn Neuroscience © 2019 Elsevier Inc. Chemotherapy has significantly increased the number of cancer survivors. However, chemotherapy itself carries various adverse effects that limit the efficacy of treatment and quality of life of the cancer patients. Most patients who have received chemotherapy report some cognitive deficit characterized by dysfunction in memory, learning, concentration, and reasoning. The phenomenon of cognitive decline developed from chemotherapy treatment is referred to as chemotherapy-induced cognitive impairment (CICI) or chemobrain. The two most common cancers occurring worldwide are lung and breast cancer. The predominant chemotherapeutic drugs used to treat lung and breast cancer are doxorubicin and cisplatin. There is evidence to suggest that both drugs potentially induce chemobrain. The evidence around the proposed pathogenesis of chemobrain caused by these two drugs is inconsistent. Understanding the underlying mechanisms involved in the development of chemobrain would aid in the prevention or treatment of the adverse effects of chemotherapy on brain. This review will summarize and discuss controversial findings and possible mechanisms involved in the development of chemobrain and the interventions which could limit it from in vitro, in vivo, and clinical studies. 2020-04-02T15:29:23Z 2020-04-02T15:29:23Z 2020-02-01 Journal 10902430 00144886 2-s2.0-85075263290 10.1016/j.expneurol.2019.113118 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075263290&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68554
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Neuroscience
spellingShingle Neuroscience
Benjamin Ongnok
Nipon Chattipakorn
Siriporn C. Chattipakorn
Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions
description © 2019 Elsevier Inc. Chemotherapy has significantly increased the number of cancer survivors. However, chemotherapy itself carries various adverse effects that limit the efficacy of treatment and quality of life of the cancer patients. Most patients who have received chemotherapy report some cognitive deficit characterized by dysfunction in memory, learning, concentration, and reasoning. The phenomenon of cognitive decline developed from chemotherapy treatment is referred to as chemotherapy-induced cognitive impairment (CICI) or chemobrain. The two most common cancers occurring worldwide are lung and breast cancer. The predominant chemotherapeutic drugs used to treat lung and breast cancer are doxorubicin and cisplatin. There is evidence to suggest that both drugs potentially induce chemobrain. The evidence around the proposed pathogenesis of chemobrain caused by these two drugs is inconsistent. Understanding the underlying mechanisms involved in the development of chemobrain would aid in the prevention or treatment of the adverse effects of chemotherapy on brain. This review will summarize and discuss controversial findings and possible mechanisms involved in the development of chemobrain and the interventions which could limit it from in vitro, in vivo, and clinical studies.
format Journal
author Benjamin Ongnok
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_facet Benjamin Ongnok
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_sort Benjamin Ongnok
title Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions
title_short Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions
title_full Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions
title_fullStr Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions
title_full_unstemmed Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions
title_sort doxorubicin and cisplatin induced cognitive impairment: the possible mechanisms and interventions
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075263290&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68554
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