Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition

Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition

Chiang Mai University (CMU) Journal of Natural Sciences is dedicated to the publication of original research in Sciences & Technology and the Health Sciences. Submissions are welcomed from CMU, as well as other Thai and foreign institutions. All submissions must be original research not previous...

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Main Authors: Eman A. El-fayoumy, anaa M. M. Shanab, Emad A. Shalaby
Language:English
Published: Chiang Mai University 2020
Subjects:
Chlorella vulgaris
Chemical compositions
Anticancer
t Antimicrobial
Defense enzymes
Online Access:http://cmuj.cmu.ac.th/uploads/journal_list_index/423142486.pdf
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68678
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-686782020-05-20T04:41:51Z Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition Eman A. El-fayoumy anaa M. M. Shanab Emad A. Shalaby Chlorella vulgaris Chemical compositions Anticancer t Antimicrobial Defense enzymes Chiang Mai University (CMU) Journal of Natural Sciences is dedicated to the publication of original research in Sciences & Technology and the Health Sciences. Submissions are welcomed from CMU, as well as other Thai and foreign institutions. All submissions must be original research not previously published or simultaneously submitted for publication. Manuscripts are peer reviewed using the double -blinded review system by at least 2 reviewers before acceptance. The CMU Journal of Natural Sciences is published four times a year, in January, April, July and October. The aim of this work was to determine the biochemical compounds and evaluate the biological activities of Chlorella vulgaris cultivated under a biotic stress condition (various Zinc and Cupper conc.). The growth rate was recorded as well as determination of active compounds, pigments and defense enzymes, in addition to the biological activities as antioxidant, antimicrobial and anticancer. The obtained results revealed that, higher copper concentrations [0.632 mg /L (Cu)] showed an inhibitory effect to growth while 1.76 mg /L (Zn) enhanced growth which reached its maximum at 25th day of cultivation. Furthermore, combination of 0.88mg/L (Zn) and 0.316mg /L (Cu) induced an increase in growth rate, catalase, tannins, lipid peroxidation and glutathioneS-transferase and a decrease in flavonoids, phenolic content, protein and antioxidant activity. Also, the results of antioxidant activity showed that, elevation of Zn conc. induced an augmentation of antioxidant activity either by DPPH(2, 2 diphenyl-1-picrylhydrazyl) or ABTS (2, 2’- azino-bis ethylbenzthiazoline-6-sulfonic acid), with maximum activity at 0.88 mg/L Zinc conc. (89.91%) even exceeded those of control (85.62%). While more elevated Zn conc. (1.76 mg/L) induced lower activity when compared with synthetic antioxidant standard (Butylated hydroxyl toluene, BHT). Concerning antimicrobial activity, Gram +ve bacteria, Staphylococcusaureus recorded moderate activity in sulfur-contained extract. Cytotoxicity of three cancer cell lines was inversely proportional to extracts conc. used, where the higher conc. (500µg/ml) showed the lowest cell viability of the tested cell lines which ranged from 22.06 to 69.89%. 0.316 mg/L (Cu) of conc. 500 µg/ml recorded the lowest cell viability of (32.166 %) in breast cell line , (22.06%) in colon cell line, and 27.18 06%) in cervical cell line. 2020-05-20T04:41:51Z 2020-05-20T04:41:51Z 2020 Chiang Mai University (CMU) Journal of Natural Sciences 19,1 (Jan-Mar 2020), p.91-123 2465-4337 http://cmuj.cmu.ac.th/uploads/journal_list_index/423142486.pdf http://cmuir.cmu.ac.th/jspui/handle/6653943832/68678 Eng Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
language English
topic Chlorella vulgaris
Chemical compositions
Anticancer
t Antimicrobial
Defense enzymes
spellingShingle Chlorella vulgaris
Chemical compositions
Anticancer
t Antimicrobial
Defense enzymes
Eman A. El-fayoumy
anaa M. M. Shanab
Emad A. Shalaby
Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition
description Chiang Mai University (CMU) Journal of Natural Sciences is dedicated to the publication of original research in Sciences & Technology and the Health Sciences. Submissions are welcomed from CMU, as well as other Thai and foreign institutions. All submissions must be original research not previously published or simultaneously submitted for publication. Manuscripts are peer reviewed using the double -blinded review system by at least 2 reviewers before acceptance. The CMU Journal of Natural Sciences is published four times a year, in January, April, July and October.
author Eman A. El-fayoumy
anaa M. M. Shanab
Emad A. Shalaby
author_facet Eman A. El-fayoumy
anaa M. M. Shanab
Emad A. Shalaby
author_sort Eman A. El-fayoumy
title Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition
title_short Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition
title_full Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition
title_fullStr Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition
title_full_unstemmed Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition
title_sort metabolomics and biological activities of chlorella vulgaris grown under modified growth medium (bg11) composition
publisher Chiang Mai University
publishDate 2020
url http://cmuj.cmu.ac.th/uploads/journal_list_index/423142486.pdf
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68678
_version_ 1681752675550494720

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