Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has b...
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th-cmuir.6653943832-69152014-08-30T03:51:23Z Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers Phothongkam S. Chancharunee S. Saovapakhiran A. Wichai U. Pohmakotr M. In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dimers 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved. 2014-08-30T03:51:23Z 2014-08-30T03:51:23Z 2012 Article in Press 0960894X 10.1016/j.bmcl.2012.10.020 BMCLE http://www.scopus.com/inward/record.url?eid=2-s2.0-84867684733&partnerID=40&md5=39febe766c46a733b4fa0592bfd96673 http://cmuir.cmu.ac.th/handle/6653943832/6915 English |
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In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dimers 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved. |
| format |
Article |
| author |
Phothongkam S. Chancharunee S. Saovapakhiran A. Wichai U. Pohmakotr M. |
| spellingShingle |
Phothongkam S. Chancharunee S. Saovapakhiran A. Wichai U. Pohmakotr M. Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers |
| author_facet |
Phothongkam S. Chancharunee S. Saovapakhiran A. Wichai U. Pohmakotr M. |
| author_sort |
Phothongkam S. |
| title |
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers |
| title_short |
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers |
| title_full |
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers |
| title_fullStr |
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers |
| title_full_unstemmed |
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers |
| title_sort |
facile synthesis and anticancer activity of c-10 non-acetal deoxoartemisinin dimers |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84867684733&partnerID=40&md5=39febe766c46a733b4fa0592bfd96673 http://cmuir.cmu.ac.th/handle/6653943832/6915 |
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1681420703171084288 |