BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution

The Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science...

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Main Authors: Faungchat Thammarakcharoen, Jintamai Suwanprateeb
Language:English
Published: Faculty of Science, Chiang Mai University 2020
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Online Access:https://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11101
http://cmuir.cmu.ac.th/jspui/handle/6653943832/69881
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-698812020-10-08T08:36:16Z BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution Faungchat Thammarakcharoen Jintamai Suwanprateeb BMP-2 hydroxyapatite calcium phosphate co-precipitation biomimetic The Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so. Bone morphogenetic protein (BMP-2) is multi-functional growth factor and widely used osteoinductive cell mediator which was loaded into the osteoconductive bone graft to accelerate bone healing and osteointegration of the graft. Rapid biomimetic co-precipitation technique by using newly developed accelerated calcium phosphate solution was investigated as a mean to enhance the incorporation of BMP-2 on three dimensionally printed porous hydroxyapatite (3DP HA) and its release characteristic compared to typical direct adsorption. Two initial BMP-2 concentrations of 1 and 10 μg/mL were employed in this study. After loading, new octacalcium phosphate leaf-like crystals were observed to form on the surface of BMP-2 loaded 3DP HA by using biomimetic co-precipitation technique at both concentrations while none was seen in the direct adsorption technique. Biomimetic co-precipitation technique yielded two times greater in total BMP-2 loading content, but displayed lower releasing rate than those of the direct adsorption technique. Cell differentiation of pre-osteoblast MC3T3-E1 on the BMP-2 loaded 3DP HA by using biomimetic co-precipitation was also greater enhanced compared to non-loaded or direct adsorbed samples. The increase in content and decrease in releasing rate of BMP-2 by using biomimetic co-precipitation technique could be related to the formation of new octacalcium phosphate crystals on the 3DP HA which incorporated BMP-2 into their structures and retarded its release. 2020-10-08T08:36:16Z 2020-10-08T08:36:16Z 2020 Chiang Mai Journal of Science 47,4 (Special Issue II : July 2020), p.723-737 2465-3845 https://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11101 http://cmuir.cmu.ac.th/jspui/handle/6653943832/69881 Eng Faculty of Science, Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
language English
topic BMP-2
hydroxyapatite
calcium phosphate
co-precipitation
biomimetic
spellingShingle BMP-2
hydroxyapatite
calcium phosphate
co-precipitation
biomimetic
Faungchat Thammarakcharoen
Jintamai Suwanprateeb
BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution
description The Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so.
author Faungchat Thammarakcharoen
Jintamai Suwanprateeb
author_facet Faungchat Thammarakcharoen
Jintamai Suwanprateeb
author_sort Faungchat Thammarakcharoen
title BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution
title_short BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution
title_full BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution
title_fullStr BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution
title_full_unstemmed BMP-2 Incorporation into 3D Printed Porous Hydroxyapatite by Rapid Biomimetic Co-Precipitation Technique Using Accelerated Calcium Phosphate Solution
title_sort bmp-2 incorporation into 3d printed porous hydroxyapatite by rapid biomimetic co-precipitation technique using accelerated calcium phosphate solution
publisher Faculty of Science, Chiang Mai University
publishDate 2020
url https://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11101
http://cmuir.cmu.ac.th/jspui/handle/6653943832/69881
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