Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

The Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science...

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Main Authors: Piyarat Sungkhaphan, Boonlom Thavornyutikarn, Pakkanun Kaewkong, Weerachai Singhatanadgit, Soraya Pornsuwan, Wanida Janvikul
Language:English
Published: Faculty of Science, Chiang Mai University 2020
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Online Access:https://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11104
http://cmuir.cmu.ac.th/jspui/handle/6653943832/69892
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spelling th-cmuir.6653943832-698922020-10-08T08:36:16Z Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment Piyarat Sungkhaphan Boonlom Thavornyutikarn Pakkanun Kaewkong Weerachai Singhatanadgit Soraya Pornsuwan Wanida Janvikul composite hydrogel mesoporous silica nanoparticles clindamycin hydrochloride The Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so. Two different porous hydrogels with and without mesoporous silica nanoparticles (MSNs) were developed and comparatively evaluated for their potential use in drug delivery applications. The hydrogels were fabricated from the MSNs-mixed and MSNs-free mixtures of poly(ethylene glycol) dimethacrylate, glycidyl methacrylate, poly(vinyl alcohol) (PVA) (porogen), and irgacure-819 (initiator). After UV curing, PVA was leached out with DI water. Then, individual hydrogels were immersed in 0.5 mL of aqueous clindamycin hydrochloride (CDM, 20 mg/mL), mixed with or without simulated body fluid (SBF) used at different ion concentrations, at 37oC for 3 days. The amounts of CDM loaded into and released from each specimen were analyzed by HPLC analysis. The SEM images of the hydrogels revealed porous structures with an average pore size in the range of 148-158 μm. The incorporation of MSNs into the hydrogel slightly increased the amounts of CDM loaded into and released from the specimen, when water was used as drug loading medium. The contents of CDM loaded and released were, however, considerably raised as a function of ion concentration of SBF used, indicating the ionic interactions among CDM, MSNs, and SBF. Furthermore, a more prolonged release of CDM was observed in these composite hydrogels, compared with that of the composite hydrogel loaded with CDM in DI water. Surprisingly, the similar in vitro antibacterial activity up to 7 days was yielded from the composite hydrogels loaded with CDM in DI water and SBF solution, even though the release profiles of CDM observed in these two hydrogels were different, implying that there might be some unreleased CDM left in the hydrogels, which could kill the bacteria. These findings strongly suggested the great potential use of this composite material in antibiotic delivery systems. 2020-10-08T08:36:16Z 2020-10-08T08:36:16Z 2020 Chiang Mai Journal of Science 47,4 (Special Issue II : July 2020), p.765-775 2465-3845 https://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11104 http://cmuir.cmu.ac.th/jspui/handle/6653943832/69892 Eng Faculty of Science, Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
language English
topic composite hydrogel
mesoporous silica nanoparticles
clindamycin hydrochloride
spellingShingle composite hydrogel
mesoporous silica nanoparticles
clindamycin hydrochloride
Piyarat Sungkhaphan
Boonlom Thavornyutikarn
Pakkanun Kaewkong
Weerachai Singhatanadgit
Soraya Pornsuwan
Wanida Janvikul
Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
description The Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so.
author Piyarat Sungkhaphan
Boonlom Thavornyutikarn
Pakkanun Kaewkong
Weerachai Singhatanadgit
Soraya Pornsuwan
Wanida Janvikul
author_facet Piyarat Sungkhaphan
Boonlom Thavornyutikarn
Pakkanun Kaewkong
Weerachai Singhatanadgit
Soraya Pornsuwan
Wanida Janvikul
author_sort Piyarat Sungkhaphan
title Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
title_short Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
title_full Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
title_fullStr Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
title_full_unstemmed Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
title_sort clindamycin hydrochloride-loaded composite hydrogel of poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and mesoporous silica nanoparticles for bacterial infection treatment
publisher Faculty of Science, Chiang Mai University
publishDate 2020
url https://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11104
http://cmuir.cmu.ac.th/jspui/handle/6653943832/69892
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