Unusual mono-reassortant of a Wa-like G1P[8] species A rotavirus containing a DS-1-like (genotype 2) NSP4 gene

• Main Authors: Tung Phan, Tomihiko Ide, Satoshi Komoto, Pattara Khamrin, Shoko Okitsu, Koki Taniguchi, Hideaki Kikuta, Niwat Maneekarn, Satoshi Hayakawa, Hiroshi Ushijima
• Format: Journal
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85088456199&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70169
• Institution: Chiang Mai University

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Species A rotaviruses are a major cause of acute gastroenteritis in infants and young children worldwide. Reassortment is a common phenomenon due to the segmented nature of the rotavirus genome. The complete coding sequences of a species A rotavirus strain isolated from the feces of a child with acute gastroenteritis in Japan in 2018 were determined using an unbiased viral metagenomics approach. The genetic analysis revealed that the rotavirus strain had an unusual genomic constellation (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1), suggesting reassortment of a genotype 1 with a genotype 2 rotavirus, from which the NSP4-encoding gene was acquired.