Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities

© 2020 The Pharmaceutical Society of Japan. Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited we...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sirada Boonyaketgoson, Yongle Du, Ana L.Valenciano Murillo, Maria B. Cassera, David G.I. Kingston, Kongkiat Trisuwan
Format:	Journal
Published:	2020
Subjects:	Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087612768&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70388
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Chiang Mai University

id	th-cmuir.6653943832-70388
record_format	dspace
spelling	th-cmuir.6653943832-703882020-10-14T08:47:12Z Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities Sirada Boonyaketgoson Yongle Du Ana L.Valenciano Murillo Maria B. Cassera David G.I. Kingston Kongkiat Trisuwan Chemistry Pharmacology, Toxicology and Pharmaceutics © 2020 The Pharmaceutical Society of Japan. Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 w ith IC50 values of 36.7 and 33.9 μM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 μM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 μM. 2020-10-14T08:28:53Z 2020-10-14T08:28:53Z 2020-07-01 Journal 13475223 00092363 2-s2.0-85087612768 10.1248/cpb.c20-00080 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087612768&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70388
institution	Chiang Mai University
building	Chiang Mai University Library
continent	Asia
country	Thailand Thailand
content_provider	Chiang Mai University Library
collection	CMU Intellectual Repository
topic	Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Chemistry Pharmacology, Toxicology and Pharmaceutics Sirada Boonyaketgoson Yongle Du Ana L.Valenciano Murillo Maria B. Cassera David G.I. Kingston Kongkiat Trisuwan Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
description	© 2020 The Pharmaceutical Society of Japan. Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 w ith IC50 values of 36.7 and 33.9 μM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 μM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 μM.
format	Journal
author	Sirada Boonyaketgoson Yongle Du Ana L.Valenciano Murillo Maria B. Cassera David G.I. Kingston Kongkiat Trisuwan
author_facet	Sirada Boonyaketgoson Yongle Du Ana L.Valenciano Murillo Maria B. Cassera David G.I. Kingston Kongkiat Trisuwan
author_sort	Sirada Boonyaketgoson
title	Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
title_short	Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
title_full	Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
title_fullStr	Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
title_full_unstemmed	Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
title_sort	flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities
publishDate	2020
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087612768&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70388
_version_	1681752893697294336

Flavanones from the twigs and barks of artocarpus lakoocha having antiplasmodial and anti-tb activities

Similar Items