Commercial Copper-Catalyzed Aerobic Oxidative Synthesis of Quinazolinones from 2-Aminobenzamide and Methanol

Commercial Copper-Catalyzed Aerobic Oxidative Synthesis of Quinazolinones from 2-Aminobenzamide and Methanol

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The focus of this study was the development of a new synthetic method for quinazolinones based on the principles of Green Chemistry. Quinazolinones were synthesized from 2-aminobenzamide using methanol as both the C1 source and a green solvent...

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Bibliographic Details
Main Authors: Sutthichat Kerdphon, Patthadon Sanghong, Jaruwan Chatwichien, Vachira Choommongkol, Puracheth Rithchumpon, Thishana Singh, Puttinan Meepowpan
Format: Journal
Published: 2020
Subjects:
Chemistry
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084550137&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70395
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Institution: Chiang Mai University
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Summary:© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The focus of this study was the development of a new synthetic method for quinazolinones based on the principles of Green Chemistry. Quinazolinones were synthesized from 2-aminobenzamide using methanol as both the C1 source and a green solvent in the presence of base Cs2CO3. Additionally, a commercially available, economical copper complex was used as a catalyst in the reaction. The desired products were achieved in moderate to high yield with up to 99 % isolated yield.

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