Lead discovery of a guanidinyl tryptophan derivative on amyloid cascade inhibition

• Main Authors: Piyapan Suwanttananuruk, Jutamas Jiaranaikulwanitch, Pornthip Waiwut, Opa Vajragupta
• Format: Journal
• Published: 2020
• Subjects: Chemistry; Materials Science
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086908160&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70409
• Institution: Chiang Mai University

© 2020 Piyapan Suwanttananuruk et al., published by De Gruyter 2020. Amyloid cascade, one of pathogenic pathways of Alzheimer's disease (AD), was focused as one of drug discovery targets. In this study, β-secretase (BACE1) inhibitors were designed aiming at the development of multifunctional co...