Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention
© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future direction...
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th-cmuir.6653943832-706442020-10-14T08:40:54Z Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention Paul K. Drain Ashley R. Bardon Jane M. Simoni Tim R. Cressey Pete Anderson Derin Sevenler Ayokunle O. Olanrewaju Monica Gandhi Connie Celum Immunology and Microbiology Medicine © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence monitoring. Recent Findings: Two cornerstones to end the HIV/AIDS pandemic are ART, which provides individual clinical benefits and eliminates forward transmission, and PrEP, which prevents HIV acquisition with high effectiveness. Maximizing the individual and public health benefits of these powerful biomedical tools requires high and sustained antiretroviral adherence. Routine monitoring of medication adherence in individuals receiving ART and PrEP may be an important component in interpreting outcomes and supporting optimal adherence. Existing practices and subjective metrics for adherence monitoring are often inaccurate or unreliable and, therefore, are generally ineffective for improving adherence. Laboratory measures of antiretroviral concentrations using liquid chromatography tandem mass spectrometry have been utilized in research settings to assess medication adherence, although these are too costly and resource-intensive for routine use. Summary: Newer, less costly technologies such as antibody-based methods can provide objective drug-level measurement and may allow for POC or near-patient adherence monitoring in clinical settings. When coupled with timely and targeted counseling, POC drug-level measures can support adherence clinic-based interventions to ART or PrEP in near real time. 2020-10-14T08:37:00Z 2020-10-14T08:37:00Z 2020-10-01 Journal 15483576 15483568 2-s2.0-85087511088 10.1007/s11904-020-00512-3 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087511088&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70644 |
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Immunology and Microbiology Medicine Paul K. Drain Ashley R. Bardon Jane M. Simoni Tim R. Cressey Pete Anderson Derin Sevenler Ayokunle O. Olanrewaju Monica Gandhi Connie Celum Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention |
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© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence monitoring. Recent Findings: Two cornerstones to end the HIV/AIDS pandemic are ART, which provides individual clinical benefits and eliminates forward transmission, and PrEP, which prevents HIV acquisition with high effectiveness. Maximizing the individual and public health benefits of these powerful biomedical tools requires high and sustained antiretroviral adherence. Routine monitoring of medication adherence in individuals receiving ART and PrEP may be an important component in interpreting outcomes and supporting optimal adherence. Existing practices and subjective metrics for adherence monitoring are often inaccurate or unreliable and, therefore, are generally ineffective for improving adherence. Laboratory measures of antiretroviral concentrations using liquid chromatography tandem mass spectrometry have been utilized in research settings to assess medication adherence, although these are too costly and resource-intensive for routine use. Summary: Newer, less costly technologies such as antibody-based methods can provide objective drug-level measurement and may allow for POC or near-patient adherence monitoring in clinical settings. When coupled with timely and targeted counseling, POC drug-level measures can support adherence clinic-based interventions to ART or PrEP in near real time. |
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Journal |
author |
Paul K. Drain Ashley R. Bardon Jane M. Simoni Tim R. Cressey Pete Anderson Derin Sevenler Ayokunle O. Olanrewaju Monica Gandhi Connie Celum |
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Paul K. Drain Ashley R. Bardon Jane M. Simoni Tim R. Cressey Pete Anderson Derin Sevenler Ayokunle O. Olanrewaju Monica Gandhi Connie Celum |
author_sort |
Paul K. Drain |
title |
Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention |
title_short |
Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention |
title_full |
Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention |
title_fullStr |
Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention |
title_full_unstemmed |
Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention |
title_sort |
point-of-care and near real-time testing for antiretroviral adherence monitoring to hiv treatment and prevention |
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2020 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087511088&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70644 |
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