The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment

© 2020 by the authors. The full-thickness articular cartilage defect (FTAC) is an abnormally severe grade of articular cartilage (AC) injury. An osteochondral autograft transfer (OAT) is the recommended treatment, but the increasing morbidity rate from osteochondral plug harvesting is a limitation....

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Main Authors: Kittiya Thunsiri, Siwasit Pitjamit, Peraphan Pothacharoen, Dumnoensun Pruksakorn, Wasawat Nakkiew, Wassanai Wattanutchariya
Format: Journal
Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/70679
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spelling th-cmuir.6653943832-706792020-10-14T08:38:13Z The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment Kittiya Thunsiri Siwasit Pitjamit Peraphan Pothacharoen Dumnoensun Pruksakorn Wasawat Nakkiew Wassanai Wattanutchariya Materials Science © 2020 by the authors. The full-thickness articular cartilage defect (FTAC) is an abnormally severe grade of articular cartilage (AC) injury. An osteochondral autograft transfer (OAT) is the recommended treatment, but the increasing morbidity rate from osteochondral plug harvesting is a limitation. Thus, the 3D-printed bilayer's bioactive-biomaterials scaffold is of major interest. Polylactic acid (PLA) and polycaprolactone (PCL) were blended with hydroxyapatite (HA) for the 3D-printed bone layer of the bilayer's bioactive-biomaterials scaffold (B-BBBS). Meanwhile, the blended PLA/PCL filament was 3D printed and combined with a chitosan (CS)/silk firoin (SF) using a lyophilization technique to fabricate the AC layer of the bilayer's bioactive-biomaterials scaffold (AC-BBBS). Material characterization and mechanical and biological tests were performed. The fabrication process consists of combining the 3D-printed structure (AC-BBBS and B-BBBS) and a lyophilized porous AC-BBBS. The morphology and printing abilities were investigated, and biological tests were performed. Finite element analysis (FEA) was performed to predict the maximum load that the bilayer's bioactive-biomaterials scaffold (BBBS) could carry. The presence of HA and CS/SF in the PLA/PCL structure increased cell proliferation. The FEA predicted the load carrying capacity to be up to 663.2 N. All tests indicated that it is possible for BBBS to be used in tissue engineering for AC and bone regeneration in FTAC treatment. 2020-10-14T08:38:13Z 2020-10-14T08:38:13Z 2020-08-01 Journal 19961944 2-s2.0-85089744619 10.3390/ma13153417 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089744619&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70679
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
topic Materials Science
spellingShingle Materials Science
Kittiya Thunsiri
Siwasit Pitjamit
Peraphan Pothacharoen
Dumnoensun Pruksakorn
Wasawat Nakkiew
Wassanai Wattanutchariya
The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment
description © 2020 by the authors. The full-thickness articular cartilage defect (FTAC) is an abnormally severe grade of articular cartilage (AC) injury. An osteochondral autograft transfer (OAT) is the recommended treatment, but the increasing morbidity rate from osteochondral plug harvesting is a limitation. Thus, the 3D-printed bilayer's bioactive-biomaterials scaffold is of major interest. Polylactic acid (PLA) and polycaprolactone (PCL) were blended with hydroxyapatite (HA) for the 3D-printed bone layer of the bilayer's bioactive-biomaterials scaffold (B-BBBS). Meanwhile, the blended PLA/PCL filament was 3D printed and combined with a chitosan (CS)/silk firoin (SF) using a lyophilization technique to fabricate the AC layer of the bilayer's bioactive-biomaterials scaffold (AC-BBBS). Material characterization and mechanical and biological tests were performed. The fabrication process consists of combining the 3D-printed structure (AC-BBBS and B-BBBS) and a lyophilized porous AC-BBBS. The morphology and printing abilities were investigated, and biological tests were performed. Finite element analysis (FEA) was performed to predict the maximum load that the bilayer's bioactive-biomaterials scaffold (BBBS) could carry. The presence of HA and CS/SF in the PLA/PCL structure increased cell proliferation. The FEA predicted the load carrying capacity to be up to 663.2 N. All tests indicated that it is possible for BBBS to be used in tissue engineering for AC and bone regeneration in FTAC treatment.
format Journal
author Kittiya Thunsiri
Siwasit Pitjamit
Peraphan Pothacharoen
Dumnoensun Pruksakorn
Wasawat Nakkiew
Wassanai Wattanutchariya
author_facet Kittiya Thunsiri
Siwasit Pitjamit
Peraphan Pothacharoen
Dumnoensun Pruksakorn
Wasawat Nakkiew
Wassanai Wattanutchariya
author_sort Kittiya Thunsiri
title The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment
title_short The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment
title_full The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment
title_fullStr The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment
title_full_unstemmed The 3D-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment
title_sort 3d-printed bilayer's bioactive-biomaterials scaffold for full-thickness articular cartilage defects treatment
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089744619&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70679
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