Expression profiling of DNA methyl transferase I (DNMT1) and efficacy of a DNA-hypomethylating agent (decitabine) in combination with chemotherapy in osteosarcoma

• Main Authors: Parunya Chaiyawat, Nutnicha Sirikaew, Piyaporn Budprom, Jeerawan Klangjorhor, Areerak Phanphaisarn, Pimpisa Teeyakasem, Jongkolnee Settakorn, Dumnoensun Pruksakorn
• Format: Journal
• Published: 2020
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85091985687&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70742
• Institution: Chiang Mai University

© 2020 Background: Abnormality in the DNA methylation process is one of the hallmarks of cancer. Emerging evidence strongly supports the idea that defects in DNA methyl transferases (DNMTs) are involved in tumor development and progression. This alteration has major effects at the transcription leve...