The dosimetric comparison between tomotherapy and RapidArc in normal tissue sparing for nasopharyngeal carcinoma

• Main Authors: Pubade Kaewpruk, Somvilai Chakrabandhu, Somsak Wanwilairat, Wannapha Nobnop
• Format: Journal
• Published: 2020
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090152332&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70767
• Institution: Chiang Mai University

© 2019 Cambridge University Press. Purpose: To compare the dosimetric results regarding the sparing effect on normal tissue between RapidArc (RA) and helical tomotherapy (HT) plans for nasopharyngeal carcinoma (NPC) patients in cases of the equal target dose controls utilising two techniques.Materials and Methods: Thirteen NPC patients treated with HT were replanned using the Varian Eclipse treatment planning system (TPS) for the RA plan. The target dose of the RA plan was optimised equally to the HT plan in terms of target coverage, dose conformity (CI) and dose homogeneity (HI) for assessing the normal tissue sparing between two techniques. All dose-volume parameters monitor units (MUs) and delivery time were also investigated.Results: All dosimetric parameter comparisons of organs-at-risk (OARs) between the RA and HT plans were not significantly different for brain stem, spinal cord and cochlea. However, the RA plan showed a significantly lower dose to the left parotid gland. The mean and median dose were significantly lower in the RA plan versus the HT plan by p-value 0·005 and 0·039, respectively. The MUs and delivery time were also significantly lower in the RA plan with a p-value of 0·00.Conclusions: With the same planning target volume coverage, homogeneity and conformity, almost all of RA and HT treatment planning met the planning goal for normal tissue sparing. There were no significant differences between the two techniques except in the left parotid gland. The RA plans were superior to HT plans by effectively reducing the MUs and treatment time.