Necrostatin-1 mitigates cognitive dysfunction in prediabetic rats with no alteration in insulin sensitivity

• Main Authors: Kewarin Jinawong, Nattayaporn Apaijai, Supawit Wongsuchai, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C. Chattipakorn
• Format: Journal
• Published: 2020
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086771033&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70807
• Institution: Chiang Mai University

© 2020 by the American Diabetes Association. Previous studies showed that 12 weeks of high-fat diet (HFD) consumption caused not only prediabetes but also cognitive decline and brain pathologies. Recently, necros-tatin-1 (nec-1), a necroptosis inhibitor, showed beneficial effects in brain against st...