The roles of resveratrol on cardiac mitochondrial function in cardiac diseases

© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Left ventricular (LV) dysfunction is commonly associated with a variety of health conditions including acute myocardial infarction and obesity/diabetes. In addition, administration of several pharmacological agents such as anticancer, an...

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Main Authors: Apiwan Arinno, Nattayaporn Apaijai, Siriporn C. Chattipakorn, Nipon Chattipakorn
Format: Journal
Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/70925
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spelling th-cmuir.6653943832-709252020-10-14T08:46:49Z The roles of resveratrol on cardiac mitochondrial function in cardiac diseases Apiwan Arinno Nattayaporn Apaijai Siriporn C. Chattipakorn Nipon Chattipakorn Medicine Nursing © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Left ventricular (LV) dysfunction is commonly associated with a variety of health conditions including acute myocardial infarction and obesity/diabetes. In addition, administration of several pharmacological agents such as anticancer, antiviral, and immunosuppressive drugs has been shown to be related with LV dysfunction. The molecular mechanism responsible for LV dysfunction has been extensively studied, and it has been proposed that the overproduction of reactive oxygen species (ROS) plays a crucial role in the regulation of this function. Mitochondria require the balance between ROS production and antioxidants to maintain their appropriate function and to prevent excessive ROS production. Thus, the excessive production of ROS and the reduced scavenging process under any pathological conditions could disrupt mitochondrial function, leading to energy depletion with subsequent cell death. Therefore, maintenance of the balance between oxidative stress and antioxidants is essential. Resveratrol, a stilbene, has been investigated extensively, and potentially used to treat or prevent various cardiovascular diseases. Resveratrol directly upregulates antioxidative capacity by increasing antioxidant genes such as heme oxygenase-1, superoxide dismutase, catalase, and glutathione. In this review, accumulated data from in vitro, ex vivo, and in vivo studies regarding the effects of resveratrol on cardiac mitochondrial function in cardiac pathologies are comprehensively summarized and discussed. Since there is no conclusive available clinical study regarding the effects of resveratrol on cardiac mitochondrial function, this review also aims to encourage more clinical investigations to confirm findings from basic research. This comprehensive review will provide insight regarding the potential mechanistic roles of resveratrol in preventing and/or treating patients with cardiovascular diseases to improve LV function and their health status. 2020-10-14T08:44:47Z 2020-10-14T08:44:47Z 2020-01-01 Journal 14366215 14366207 2-s2.0-85085066463 10.1007/s00394-020-02256-7 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085066463&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70925
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
topic Medicine
Nursing
spellingShingle Medicine
Nursing
Apiwan Arinno
Nattayaporn Apaijai
Siriporn C. Chattipakorn
Nipon Chattipakorn
The roles of resveratrol on cardiac mitochondrial function in cardiac diseases
description © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Left ventricular (LV) dysfunction is commonly associated with a variety of health conditions including acute myocardial infarction and obesity/diabetes. In addition, administration of several pharmacological agents such as anticancer, antiviral, and immunosuppressive drugs has been shown to be related with LV dysfunction. The molecular mechanism responsible for LV dysfunction has been extensively studied, and it has been proposed that the overproduction of reactive oxygen species (ROS) plays a crucial role in the regulation of this function. Mitochondria require the balance between ROS production and antioxidants to maintain their appropriate function and to prevent excessive ROS production. Thus, the excessive production of ROS and the reduced scavenging process under any pathological conditions could disrupt mitochondrial function, leading to energy depletion with subsequent cell death. Therefore, maintenance of the balance between oxidative stress and antioxidants is essential. Resveratrol, a stilbene, has been investigated extensively, and potentially used to treat or prevent various cardiovascular diseases. Resveratrol directly upregulates antioxidative capacity by increasing antioxidant genes such as heme oxygenase-1, superoxide dismutase, catalase, and glutathione. In this review, accumulated data from in vitro, ex vivo, and in vivo studies regarding the effects of resveratrol on cardiac mitochondrial function in cardiac pathologies are comprehensively summarized and discussed. Since there is no conclusive available clinical study regarding the effects of resveratrol on cardiac mitochondrial function, this review also aims to encourage more clinical investigations to confirm findings from basic research. This comprehensive review will provide insight regarding the potential mechanistic roles of resveratrol in preventing and/or treating patients with cardiovascular diseases to improve LV function and their health status.
format Journal
author Apiwan Arinno
Nattayaporn Apaijai
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_facet Apiwan Arinno
Nattayaporn Apaijai
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_sort Apiwan Arinno
title The roles of resveratrol on cardiac mitochondrial function in cardiac diseases
title_short The roles of resveratrol on cardiac mitochondrial function in cardiac diseases
title_full The roles of resveratrol on cardiac mitochondrial function in cardiac diseases
title_fullStr The roles of resveratrol on cardiac mitochondrial function in cardiac diseases
title_full_unstemmed The roles of resveratrol on cardiac mitochondrial function in cardiac diseases
title_sort roles of resveratrol on cardiac mitochondrial function in cardiac diseases
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085066463&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70925
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