Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease

© 2020, IPNA. Background: Vitamin C deficiency is common in chronic kidney disease (CKD) due to losses through dialysis and dietary intake below requirement. We investigated prevalence of vitamin C deficiency and impact of vitamin C treatment in deficient/insufficient patients. Methods: A prospectiv...

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Main Authors: Nattaphorn Hongsawong, Notethasoung Chawprang, Kulnipa Kittisakmontri, Parach Vittayananan, Konggrapun Srisuwan, Wattana Chartapisak
Format: Journal
Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/70935
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spelling th-cmuir.6653943832-709352020-10-14T08:45:06Z Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease Nattaphorn Hongsawong Notethasoung Chawprang Kulnipa Kittisakmontri Parach Vittayananan Konggrapun Srisuwan Wattana Chartapisak Medicine © 2020, IPNA. Background: Vitamin C deficiency is common in chronic kidney disease (CKD) due to losses through dialysis and dietary intake below requirement. We investigated prevalence of vitamin C deficiency and impact of vitamin C treatment in deficient/insufficient patients. Methods: A prospective cohort study in patients aged 1–18 years with CKD stages 4 and 5D collected demographic data including underlying disease, treatment, and anthropometric assessment. Vitamin C intake was assessed using 24-h dietary recall. Hemoglobin, iron status, serum vitamin C, and serum oxalate were measured at baseline and after treatment. Vitamin C (250 mg/day) was given orally for 3 months to deficient/insufficient patients. Results: Nineteen patients (mean age 12.00 ± 4.1 years) showed prevalence of 10.6% vitamin C insufficiency and 78.9% deficiency. There were no associations between vitamin C level and daily vitamin C intake (p = 0.64) or nutritional status (p = 0.87). Median serum vitamin C was 1.51 (0.30–1.90) mg/L. In 16 patients receiving treatment, median serum vitamin C increased from 1.30 (0.23–1.78) to 3.22 (1.77–5.96) mg/L (p = 0.008) without increasing serum oxalate (79.92 (56.6–106.84) vs. 80.47 (56.88–102.95) μmol/L, p = 0.82). However, 62.5% failed to achieve normal vitamin C levels. Ordinal regression analysis revealed patients with non-oligoanuric CKD were less likely to achieve normal vitamin C levels (β = − 3.41, p = 0.03). Conclusion: We describe high prevalence of vitamin C insufficiency/deficiency among pediatric CKD patients. Vitamin C levels could not be solely predicted by nutritional status or daily intake. The treatment regimen raised serum vitamin C without increasing serum oxalate; however, it was largely insufficient to normalize levels, particularly in non-oligoanuric CKD. [Figure not available: see fulltext.]. 2020-10-14T08:45:06Z 2020-10-14T08:45:06Z 2020-01-01 Journal 1432198X 0931041X 2-s2.0-85088098349 10.1007/s00467-020-04662-9 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85088098349&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70935
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Nattaphorn Hongsawong
Notethasoung Chawprang
Kulnipa Kittisakmontri
Parach Vittayananan
Konggrapun Srisuwan
Wattana Chartapisak
Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease
description © 2020, IPNA. Background: Vitamin C deficiency is common in chronic kidney disease (CKD) due to losses through dialysis and dietary intake below requirement. We investigated prevalence of vitamin C deficiency and impact of vitamin C treatment in deficient/insufficient patients. Methods: A prospective cohort study in patients aged 1–18 years with CKD stages 4 and 5D collected demographic data including underlying disease, treatment, and anthropometric assessment. Vitamin C intake was assessed using 24-h dietary recall. Hemoglobin, iron status, serum vitamin C, and serum oxalate were measured at baseline and after treatment. Vitamin C (250 mg/day) was given orally for 3 months to deficient/insufficient patients. Results: Nineteen patients (mean age 12.00 ± 4.1 years) showed prevalence of 10.6% vitamin C insufficiency and 78.9% deficiency. There were no associations between vitamin C level and daily vitamin C intake (p = 0.64) or nutritional status (p = 0.87). Median serum vitamin C was 1.51 (0.30–1.90) mg/L. In 16 patients receiving treatment, median serum vitamin C increased from 1.30 (0.23–1.78) to 3.22 (1.77–5.96) mg/L (p = 0.008) without increasing serum oxalate (79.92 (56.6–106.84) vs. 80.47 (56.88–102.95) μmol/L, p = 0.82). However, 62.5% failed to achieve normal vitamin C levels. Ordinal regression analysis revealed patients with non-oligoanuric CKD were less likely to achieve normal vitamin C levels (β = − 3.41, p = 0.03). Conclusion: We describe high prevalence of vitamin C insufficiency/deficiency among pediatric CKD patients. Vitamin C levels could not be solely predicted by nutritional status or daily intake. The treatment regimen raised serum vitamin C without increasing serum oxalate; however, it was largely insufficient to normalize levels, particularly in non-oligoanuric CKD. [Figure not available: see fulltext.].
format Journal
author Nattaphorn Hongsawong
Notethasoung Chawprang
Kulnipa Kittisakmontri
Parach Vittayananan
Konggrapun Srisuwan
Wattana Chartapisak
author_facet Nattaphorn Hongsawong
Notethasoung Chawprang
Kulnipa Kittisakmontri
Parach Vittayananan
Konggrapun Srisuwan
Wattana Chartapisak
author_sort Nattaphorn Hongsawong
title Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease
title_short Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease
title_full Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease
title_fullStr Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease
title_full_unstemmed Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease
title_sort vitamin c deficiency and impact of vitamin c administration among pediatric patients with advanced chronic kidney disease
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85088098349&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70935
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