d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats

© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Obesity-induced insulin resistant is associated with cardiovascular diseases via impairing cardiac mitochondria. Recently, d-allulose could protect β-islets and improve insulin resistance. However, the effects of d-allulose on t...

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Main Authors: Wanpitak Pongkan, Kewarin Jinawong, Wasana Pratchayasakul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Masaaki Tokuda, Siriporn C. Chattipakorn, Nipon Chattipakorn
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Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/70941
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spelling th-cmuir.6653943832-709412020-10-14T08:46:52Z d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats Wanpitak Pongkan Kewarin Jinawong Wasana Pratchayasakul Thidarat Jaiwongkam Sasiwan Kerdphoo Masaaki Tokuda Siriporn C. Chattipakorn Nipon Chattipakorn Medicine Nursing © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Obesity-induced insulin resistant is associated with cardiovascular diseases via impairing cardiac mitochondria. Recently, d-allulose could protect β-islets and improve insulin resistance. However, the effects of d-allulose on the heart and cardiac mitochondrial function under obesity-induced insulin-resistant condition has not been investigated. In this study, we aimed to investigate the effects of d-allulose on metabolic parameters, cardiac function, heart rate variability (HRV), cardiac mitochondrial function, and apoptosis in the heart of obesity-induced insulin-resistant rats induced by chronic high fat diet consumption. Methods: Male Wistar rats (n = 24) received a normal fat diet (ND) or high fat diet (HFD) for 12 weeks. Then, HFD group was randomly divided into three subgroups to receive (1) HFD with distilled water, (2) HFD with 3% D-allulose 1.9 g/ kg·BW/ day (HFR), and (3) HFD with metformin 300 mg/kg·BW/ day (HFM) by diluted in drinking water daily for 12 weeks. At week 24, proposed study parameters were investigated. Results: Chronic HFD consumption induced obesity-induced insulin resistant in rats and high fat diet impaired cardiac function and HRV. HFR rats had improved insulin sensitivity as indicated by decreasing HOMA index, plasma insulin, whereas HFM decreased body weight, visceral fat, plasma cholesterol, and plasma LDL. HFR and HFM provided similar efficacy in improving HRV and attenuating cardiac mitochondrial dysfunction, leading to improved cardiac function. Conclusions: Even though this is the first investigation of the d-allulose impact on the heart with a relatively small sample size, it clearly demonstrated a beneficial effect on the heart. d-allulose exerted a therapeutic effect on metabolic parameters except for body weight and lipid profiles and provided cardioprotective effects similar to metformin via attenuating cardiac mitochondrial function in obesity-induced insulin-resistant rats. 2020-10-14T08:45:14Z 2020-10-14T08:45:14Z 2020-01-01 Journal 14366215 14366207 2-s2.0-85091874942 10.1007/s00394-020-02394-y https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85091874942&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70941
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
topic Medicine
Nursing
spellingShingle Medicine
Nursing
Wanpitak Pongkan
Kewarin Jinawong
Wasana Pratchayasakul
Thidarat Jaiwongkam
Sasiwan Kerdphoo
Masaaki Tokuda
Siriporn C. Chattipakorn
Nipon Chattipakorn
d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats
description © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Obesity-induced insulin resistant is associated with cardiovascular diseases via impairing cardiac mitochondria. Recently, d-allulose could protect β-islets and improve insulin resistance. However, the effects of d-allulose on the heart and cardiac mitochondrial function under obesity-induced insulin-resistant condition has not been investigated. In this study, we aimed to investigate the effects of d-allulose on metabolic parameters, cardiac function, heart rate variability (HRV), cardiac mitochondrial function, and apoptosis in the heart of obesity-induced insulin-resistant rats induced by chronic high fat diet consumption. Methods: Male Wistar rats (n = 24) received a normal fat diet (ND) or high fat diet (HFD) for 12 weeks. Then, HFD group was randomly divided into three subgroups to receive (1) HFD with distilled water, (2) HFD with 3% D-allulose 1.9 g/ kg·BW/ day (HFR), and (3) HFD with metformin 300 mg/kg·BW/ day (HFM) by diluted in drinking water daily for 12 weeks. At week 24, proposed study parameters were investigated. Results: Chronic HFD consumption induced obesity-induced insulin resistant in rats and high fat diet impaired cardiac function and HRV. HFR rats had improved insulin sensitivity as indicated by decreasing HOMA index, plasma insulin, whereas HFM decreased body weight, visceral fat, plasma cholesterol, and plasma LDL. HFR and HFM provided similar efficacy in improving HRV and attenuating cardiac mitochondrial dysfunction, leading to improved cardiac function. Conclusions: Even though this is the first investigation of the d-allulose impact on the heart with a relatively small sample size, it clearly demonstrated a beneficial effect on the heart. d-allulose exerted a therapeutic effect on metabolic parameters except for body weight and lipid profiles and provided cardioprotective effects similar to metformin via attenuating cardiac mitochondrial function in obesity-induced insulin-resistant rats.
format Journal
author Wanpitak Pongkan
Kewarin Jinawong
Wasana Pratchayasakul
Thidarat Jaiwongkam
Sasiwan Kerdphoo
Masaaki Tokuda
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_facet Wanpitak Pongkan
Kewarin Jinawong
Wasana Pratchayasakul
Thidarat Jaiwongkam
Sasiwan Kerdphoo
Masaaki Tokuda
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_sort Wanpitak Pongkan
title d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats
title_short d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats
title_full d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats
title_fullStr d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats
title_full_unstemmed d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats
title_sort d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85091874942&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70941
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