Urine tenofovir concentrations correlate with plasma and relate to tenofovir disoproxil fumarate adherence: A randomized, directly observed pharmacokinetic trial (target study)

• Main Authors: Paul K. Drain, Rachel W. Kubiak, Oraphan Siriprakaisil, Virat Klinbuayaem, Justice Quame-Amaglo, Praornsuda Sukrakanchana, Suriyan Tanasri, Pimpinun Punyati, Wasna Sirirungsi, Ratchada Cressey, Peter Bacchetti, Hideaki Okochi, Jared M. Baeten, Monica Gandhi, Tim R. Cressey
• Format: Journal
• Published: 2020
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084271956&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70968
• Institution: Chiang Mai University

© The Author(s) 2019. Background. Direct measurement of tenofovir (TFV) in urine could be an objective measure to monitor adherence to preexposure prophylaxis (PrEP) or TFV-based antiretroviral therapy (ART). Methods. We conducted a 3-arm randomized, pharmacokinetic study of tenofovir disoproxil fum...