PCSK9 inhibitor effectively attenuates cardiometabolic impairment in obese-insulin resistant rats

• Main Authors: Patchareeya Amput, Siripong Palee, Busarin Arunsak, Wasana Pratchayasakul, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
• Format: Journal
• Published: 2020
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087666036&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/71014
• Institution: Chiang Mai University

© 2020 Elsevier B.V. Long-term high-fat diet consumption causes obese-insulin resistance and cardiac mitochondrial dysfunction, leading to impaired left ventricular (LV) function. Atorvastatin effectively improved lipid profiles in obese patients. However, inadequate reduction in low density lipopro...