Intranasal niosomal in situ gel as a promising approach for enhancing flibanserin bioavailability and brain delivery: In vitro optimization and ex vivo/in vivo evaluation

• Main Authors: Usama A. Fahmy, Shaimaa M. Badr-Eldin, Osama A.A. Ahmed, Hibah M. Aldawsari, Singkome Tima, Hani Z. Asfour, Mohammed W. Al-Rabia, Aya A. Negm, Muhammad H. Sultan, Osama A.A. Madkhali, Nabil A. Alhakamy
• Format: Journal
• Published: 2020
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085699575&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/71021
• Institution: Chiang Mai University

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavaila...