Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. The work aimed to develop Centella asiatica extract-loaded niosomes (CAE-Nio) and surface modified niosomes by hyaluronic acid (CAE-Nio-HA) to enhance transdermal penetration. Niosome formulations were prepared by film hydra...

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Main Authors: Panikchar Wichayapreechar, Songyot Anuchapreeda, Rungsinee Phongpradist, Wandee Rungseevijitprapa, Chadarat Ampasavate
Format: Journal
Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/71025
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spelling th-cmuir.6653943832-710252020-10-14T08:47:25Z Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes Panikchar Wichayapreechar Songyot Anuchapreeda Rungsinee Phongpradist Wandee Rungseevijitprapa Chadarat Ampasavate Pharmacology, Toxicology and Pharmaceutics © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. The work aimed to develop Centella asiatica extract-loaded niosomes (CAE-Nio) and surface modified niosomes by hyaluronic acid (CAE-Nio-HA) to enhance transdermal penetration. Niosome formulations were prepared by film hydration method using Tween 60 and Span 60 as nonionic surfactants, cholesterol and various CAE contents. Various HA concentrations were investigated to obtain optimized CAE-Nio enhancing further skin penetration. Results showed that niosomes prepared from Tween 60 yielded suitable CAE encapsulated niosomes with mean particle size and zeta-potential of 155 nm and −15 mV, respectively. The niosomes exhibited high encapsulation efficiency (%EE) and drug loading capacity (%DL) of 71–77% and 3–7%, respectively. Incorporating HA to niosome decreased %DL and caused larger particle size and increased zeta-potential in a dose dependent manner while %EE remained unaffected. The sustained-release behaviour of CAE from all niosomes was under a diffusion controlled mechanism. Asiaticoside, a relatively polar compound from CAE-Nio-HA could penetrate through the stratum corneum and dermis in a larger amount than from CAE-Nio and CAE solution. CAE-Nio-HA formulations showed good stability under low temperature (4 °C and 25 °C) for periods longer than 4 months. In conclusion, the developed Nio-HA is a promising delivery system for asiaticoside to enhanced dermal absorption, permeation and accumulation in viable epidermis and dermis layers. This system can also be applied to other hydrophilic natural active compounds. 2020-10-14T08:47:25Z 2020-10-14T08:47:25Z 2020-04-02 Journal 15322394 08982104 2-s2.0-85084694172 10.1080/08982104.2019.1614952 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084694172&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/71025
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Panikchar Wichayapreechar
Songyot Anuchapreeda
Rungsinee Phongpradist
Wandee Rungseevijitprapa
Chadarat Ampasavate
Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
description © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. The work aimed to develop Centella asiatica extract-loaded niosomes (CAE-Nio) and surface modified niosomes by hyaluronic acid (CAE-Nio-HA) to enhance transdermal penetration. Niosome formulations were prepared by film hydration method using Tween 60 and Span 60 as nonionic surfactants, cholesterol and various CAE contents. Various HA concentrations were investigated to obtain optimized CAE-Nio enhancing further skin penetration. Results showed that niosomes prepared from Tween 60 yielded suitable CAE encapsulated niosomes with mean particle size and zeta-potential of 155 nm and −15 mV, respectively. The niosomes exhibited high encapsulation efficiency (%EE) and drug loading capacity (%DL) of 71–77% and 3–7%, respectively. Incorporating HA to niosome decreased %DL and caused larger particle size and increased zeta-potential in a dose dependent manner while %EE remained unaffected. The sustained-release behaviour of CAE from all niosomes was under a diffusion controlled mechanism. Asiaticoside, a relatively polar compound from CAE-Nio-HA could penetrate through the stratum corneum and dermis in a larger amount than from CAE-Nio and CAE solution. CAE-Nio-HA formulations showed good stability under low temperature (4 °C and 25 °C) for periods longer than 4 months. In conclusion, the developed Nio-HA is a promising delivery system for asiaticoside to enhanced dermal absorption, permeation and accumulation in viable epidermis and dermis layers. This system can also be applied to other hydrophilic natural active compounds.
format Journal
author Panikchar Wichayapreechar
Songyot Anuchapreeda
Rungsinee Phongpradist
Wandee Rungseevijitprapa
Chadarat Ampasavate
author_facet Panikchar Wichayapreechar
Songyot Anuchapreeda
Rungsinee Phongpradist
Wandee Rungseevijitprapa
Chadarat Ampasavate
author_sort Panikchar Wichayapreechar
title Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
title_short Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
title_full Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
title_fullStr Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
title_full_unstemmed Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
title_sort dermal targeting of centella asiatica extract using hyaluronic acid surface modified niosomes
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084694172&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/71025
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