Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy

Objectives: To evaluate the effect of haematological alterations resulting from antiretroviral therapy (ART) on the diagnosis of thalassaemia carriers in HIV-1-infected Thai patients. Methods: Complete blood cell counts, osmotic fragility (OF) test and haemoglobin (Hb)-A2 values were measured in blo...

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Main Authors: Pornprasert S., Leechanachai P., Klinbuayaem V., Leenasirimakul P., Sukunthamala K., Thunjai B., Phusua A., Saetung R., Sanguansermsri T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-52649126270&partnerID=40&md5=64d2948d43fdc62ea610066c8689cfa2
http://www.ncbi.nlm.nih.gov/pubmed/18643855
http://cmuir.cmu.ac.th/handle/6653943832/722
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-7222014-08-29T09:02:01Z Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy Pornprasert S. Leechanachai P. Klinbuayaem V. Leenasirimakul P. Sukunthamala K. Thunjai B. Phusua A. Saetung R. Sanguansermsri T. Objectives: To evaluate the effect of haematological alterations resulting from antiretroviral therapy (ART) on the diagnosis of thalassaemia carriers in HIV-1-infected Thai patients. Methods: Complete blood cell counts, osmotic fragility (OF) test and haemoglobin (Hb)-A2 values were measured in blood samples of 52 antiretroviral-treated and 14 untreated HIV-1-infected patients. Data were analysed according to thalassaemia type and ART. Results: Sixteen patients carried at least one of the investigated thalassaemia types and most of them (87.5%) received ART. Their red cell indices [mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC) and red blood cell distribution width (RDW)], OF test and Hb-A2 values were observed within the critical criteria of each thalassaemia type. Normocytic red cells were observed in α-thalassaemia and Hb-E trait. Among HIV-1-infected patients who are non-thalassaemia carriers, higher values of Hb-A2, MCH, macrocytosis and lower red cell counts were observed in the treated group. Values of RDW, MCHC and OF test for treated and untreated groups were in the normal range. Five treated patients had Hb-A2 values within the critical criteria of β-thalassaemia carriers but β-thalassaemia gene mutations were not observed by polymerase chain reaction analysis. Conclusions: ART can alter many haematological figures. Therefore, diagnosis of thalassaemia should be evaluated carefully in combination with those parameters. © 2008 British HIV Association. 2014-08-29T09:02:01Z 2014-08-29T09:02:01Z 2008 Article 14642662 10.1111/j.1468-1293.2008.00617.x 18643855 HMIEA http://www.scopus.com/inward/record.url?eid=2-s2.0-52649126270&partnerID=40&md5=64d2948d43fdc62ea610066c8689cfa2 http://www.ncbi.nlm.nih.gov/pubmed/18643855 http://cmuir.cmu.ac.th/handle/6653943832/722 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objectives: To evaluate the effect of haematological alterations resulting from antiretroviral therapy (ART) on the diagnosis of thalassaemia carriers in HIV-1-infected Thai patients. Methods: Complete blood cell counts, osmotic fragility (OF) test and haemoglobin (Hb)-A2 values were measured in blood samples of 52 antiretroviral-treated and 14 untreated HIV-1-infected patients. Data were analysed according to thalassaemia type and ART. Results: Sixteen patients carried at least one of the investigated thalassaemia types and most of them (87.5%) received ART. Their red cell indices [mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC) and red blood cell distribution width (RDW)], OF test and Hb-A2 values were observed within the critical criteria of each thalassaemia type. Normocytic red cells were observed in α-thalassaemia and Hb-E trait. Among HIV-1-infected patients who are non-thalassaemia carriers, higher values of Hb-A2, MCH, macrocytosis and lower red cell counts were observed in the treated group. Values of RDW, MCHC and OF test for treated and untreated groups were in the normal range. Five treated patients had Hb-A2 values within the critical criteria of β-thalassaemia carriers but β-thalassaemia gene mutations were not observed by polymerase chain reaction analysis. Conclusions: ART can alter many haematological figures. Therefore, diagnosis of thalassaemia should be evaluated carefully in combination with those parameters. © 2008 British HIV Association.
format Article
author Pornprasert S.
Leechanachai P.
Klinbuayaem V.
Leenasirimakul P.
Sukunthamala K.
Thunjai B.
Phusua A.
Saetung R.
Sanguansermsri T.
spellingShingle Pornprasert S.
Leechanachai P.
Klinbuayaem V.
Leenasirimakul P.
Sukunthamala K.
Thunjai B.
Phusua A.
Saetung R.
Sanguansermsri T.
Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy
author_facet Pornprasert S.
Leechanachai P.
Klinbuayaem V.
Leenasirimakul P.
Sukunthamala K.
Thunjai B.
Phusua A.
Saetung R.
Sanguansermsri T.
author_sort Pornprasert S.
title Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy
title_short Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy
title_full Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy
title_fullStr Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy
title_full_unstemmed Effect of haematological alterations on thalassaemia investigation in HIV-1-infected Thai patients receiving antiretroviral therapy
title_sort effect of haematological alterations on thalassaemia investigation in hiv-1-infected thai patients receiving antiretroviral therapy
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-52649126270&partnerID=40&md5=64d2948d43fdc62ea610066c8689cfa2
http://www.ncbi.nlm.nih.gov/pubmed/18643855
http://cmuir.cmu.ac.th/handle/6653943832/722
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