Improved SCFV ANTI-HIV-1 P17 binding affinity guided from the theoretical calculation of pairwise decomposition energies and Computational Alanine Scanning

• Main Authors: Tue-Ngeun P., Kodchakorn K., Nimmanpipug P., Lawan N., Nangola S., Tayapiwatana C., Rahman N.A., Zain S.M., Lee V.S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84888588591&partnerID=40&md5=df2c016f0f2722dad0a26d2450155d2f; http://cmuir.cmu.ac.th/handle/6653943832/7230
• Institution: Chiang Mai University

Computational approaches have been used to evaluate and define important residues for protein-protein interactions, especially antigen-antibody complexes. In our previous study, pairwise decomposition of residue interaction energies of single chain Fv with HIV-1 p17 epitope variants has indicated th...